Multifunctional graphene oxide for bioimaging: emphasis on biological research
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Do Won Hwang
Do Won Hwang received his PhD degree in the “Program in Neuroscience” in 2009 from Seoul National University. He is currently the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received an achievement award in the field of radio-nanotechnology in 2015. His research interests focus on the biomedical application using biocompatible multifunctional nanomaterials for disease theranostics, stem cell monitoring in regenerative medicine and image-guided exosome tracing in vivo.
Byung Hee Hong received the PhD degree in Chemistry in 2002 from POSTECH in Korea. After his postdoctoral training was completed his at Columbia University, he joined the Department of Chemistry, Sungkyunkwan University (SKKU) as an Assistant Professor, in 2007. He is now an Associate Professor in the Department of Chemistry at Seoul National University and also a Visiting Associate in the Department of Physics at Harvard University. He pioneered the large-scale synthesis of graphene by CVD, which triggered chemical research studies toward the practical applications of graphene.
Dong Soo Lee is a nuclear medicine physician and Professor in the Department of Nuclear Medicine at Seoul National University (SNU) and SNU Hospital since 1990. He is also chairman of Molecular Medicine and Biopharmaceutical Sciences. He is the Director of Bio-MAX/N-Bio which is the Biotechnology Research Institute of SNU. He founded the Korean Society for Nanomedicine and was its first president in 2012 to advance nanomedicine research. His major interest is in radionanomedicine, which is the combination of nuclear medicine and nanomedicine.
Abstract
Graphene oxide (GO) nanomaterials offer a wide range of bioimaging applicability. Almost complete quenching ability of fluorescence by GO and natural interaction of GO with single stranded nucleic acid made GO a useful and intriguing multifunctional nanoplatform both as a biosensor for in vitro microplate diagnostics and as a drug delivery carrier for targeted delivery. GO’s large surface area and strong near infrared absorbance contribute to enhancement of a therapeutic effect with abundant loading of drugs for possible photothermal and photodynamic therapy. Bioimaging capability of GO made it a good theranostic tool, while enabling tracing in vivo pharmacokinetics during concurrent treatment. Fluorescence, either signal on or off, Raman and surface-enhanced Raman scattering (SERs), photoacoustic, and radionuclide imaging modalities can be used for theranostic purposes using GO nanomaterials. In this review, we highlight current applications of GO for bioimaging that are classified into in vitro microplate, in vitro cellular and in vivo bioimaging.
About the authors
Do Won Hwang received his PhD degree in the “Program in Neuroscience” in 2009 from Seoul National University. He is currently the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received an achievement award in the field of radio-nanotechnology in 2015. His research interests focus on the biomedical application using biocompatible multifunctional nanomaterials for disease theranostics, stem cell monitoring in regenerative medicine and image-guided exosome tracing in vivo.
Byung Hee Hong received the PhD degree in Chemistry in 2002 from POSTECH in Korea. After his postdoctoral training was completed his at Columbia University, he joined the Department of Chemistry, Sungkyunkwan University (SKKU) as an Assistant Professor, in 2007. He is now an Associate Professor in the Department of Chemistry at Seoul National University and also a Visiting Associate in the Department of Physics at Harvard University. He pioneered the large-scale synthesis of graphene by CVD, which triggered chemical research studies toward the practical applications of graphene.
Dong Soo Lee is a nuclear medicine physician and Professor in the Department of Nuclear Medicine at Seoul National University (SNU) and SNU Hospital since 1990. He is also chairman of Molecular Medicine and Biopharmaceutical Sciences. He is the Director of Bio-MAX/N-Bio which is the Biotechnology Research Institute of SNU. He founded the Korean Society for Nanomedicine and was its first president in 2012 to advance nanomedicine research. His major interest is in radionanomedicine, which is the combination of nuclear medicine and nanomedicine.
Acknowledgments
This research was supported by the Korean Health Technology R&D Project (HI13C-1299-010013) and the Ministry of Health and Welfare, Republic of Korea (HI14C1277).
Conflict of interest statement: The authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- In this issue
- News
- CLINAM summit May 7–10, 2017
- Review
- Multifunctional graphene oxide for bioimaging: emphasis on biological research
- Mini Review
- The role of thromboxane A2 in complement activation-related pseudoallergy
- Original Articles
- Biomimetic nanostructures for the silicone-biosystem interface: tuning oxygen-plasma treatments of polydimethylsiloxane
- A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo
Artikel in diesem Heft
- Frontmatter
- In this issue
- News
- CLINAM summit May 7–10, 2017
- Review
- Multifunctional graphene oxide for bioimaging: emphasis on biological research
- Mini Review
- The role of thromboxane A2 in complement activation-related pseudoallergy
- Original Articles
- Biomimetic nanostructures for the silicone-biosystem interface: tuning oxygen-plasma treatments of polydimethylsiloxane
- A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo
