A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo
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Adny Henrique Silva
Adny Henrique Silva obtained her PhD (2015) and her Master’s degree (2011) in Pharmacy from the Federal University of Santa Catarina, Florianópolis, Brazil. She is at present, a postdoctoral researcher in Biochemistry department of the same University. Her PhD research was on “evaluation of nanoparticles toxicity using in vitro, in vivo, ex vivo and in silico models”. During this period, she also had the opportunity to participate in other projects that were anticancer-related, including the gene modulation through siRNA delivery using nanocarriers. She is experienced in cell biology, biochemistry, toxicology and nanotechnology. She has been working for the past 7 years on the investigation of antitumor properties of new molecules and new strategies for cancer diagnosis as well as new strategies to study the toxicity of nanoparticles. She also had the opportunity of 10 months’ collaborative research at the University of Liverpool, England.
,
Enio Lima Jr
Enio Lima Jr works in the Centro Atómico Bariloche/CONICET, Argentina, as an independent researcher. He graduated in Physics and with a PhD in Physics of condensed matter at the Universidade Federal de Santa Catarina, Brazil, he has been working for more than 10 years in the study of magnetic nanoparticles and their applications.
Marcelo Vasquez Mansilla was born in Buenos Aires, Argentina in 1972. He received his Bachelor’s degree in Physics from Universidad Nacional de Cuyo, Argentina in 1997 and his PhD in Physics in 2004. He worked for 2 years at Istituto di Struttura della Materia del CNR di Roma and since 2007 he has held a position as a researcher at the Magnetic Resonance Laboratory in Centro Atomico Bariloche, Argentina. His current research focus on magnetism of nanostructure materials like magnetic nanoparticles and thin films. He is also involved in applied research using nanoparticles in medicine as magnetic hiperthermia, drug delivery and sensors.
Roberto Daniel Zysler obtained his MS degree in Physics in 1985 and in 1992 he obtained his PhD in Physics at the Instituto Balseiro (Universidad Nacional de Cuyo, Argentina). In 1995 he started a permanent research position as a scientific researcher (CONICET, Argentina) at the Magnetism Group of the Centro Atómico Bariloche (at the Magnetic Resonance Laboratory), and from this time he has worked on magnetic nanoparticles properties and their applications in bio-medicine. He is a Professor at the Instituto Balseior and advisor of Master’s degree thesis and PhD thesis for Physics candidates. He has over 150 scientific publication in international scientific journals and presented over 170 congress communication contributions at international scientific meetings.
Mary Luz Mojica Pisciotti obtained her PhD in Physics and her MSc in Medical Physics from Balseiro Institute and National University of Cuyo in Argentina and her BSc in Physics from the National University of Colombia. She is currently a postdoctoral researcher at the National Atomic Energy Commission (CNEA) in Bariloche. Her research is focused on the use of magnetic nanoparticles (MNPs) in medicine, particularly in magnetic hyperthermia and in the application of these nanomaterials in contrast-enhanced magnetic resonance imaging (MRI). Mary has had the opportunity of working on various aspects of MNPs, including synthesis, magnetic and non-magnetic properties characterization and heating mechanisms. Additionally she has performed physical and biological experiments with iron oxide MNPs in different systems, including cellular and animal models. Her background has allowed her to explore the potential of working with interdisciplinary teams.
Claudriana Locatelli obtained her PhD in Pharmacy in 2009. She is currently a Professor of Biochemistry at the University of the West of Santa Catarina (Unoesc). She contributes as a Professor at Unoesc Postgraduate Program of Bioscience and Health, and to the Program of Science and Biotechnology. She has experience in antioxidants of natural products and cancer treatment.
Rajith Kumar Reddy Rajoli graduated in Pharmacy from the Birla Institute of Technology and Science, Pilani (BITS-Pilani), India in 2009. Later, he received his MSc in drug delivery from University College London, UK in 2011 and in 2017 he obtained a PhD in Pharmacology from the University of Liverpool, Liverpool, UK. Following his PhD, he has been working as a research associate in the Molecular and Clinical Pharmacology department at the University of Liverpool. His current research focuses on informing the design of long-acting nanoparticles for intramuscular, subcutaneous and transdermal administration using physiologically based pharmacokinetic (PBPK) modeling.
Andrew Owen is Professor of Pharmacology at the University of Liverpool. He is Chair of the British Society for Nanomedicine, a Fellow of the Royal Society of Biology, and a Fellow of the British Pharmacological Society. His clinical and basic research focuses on understanding the mechanisms that underpin inter-patient variability in pharmacokinetics and pharmacodynamics, and to employ such knowledge to accelerate nanomedicine translation. His work is supported by the US Agency for International Development, the US National Institutes for Health, the UK Medical Research Council, the European Commission and the UK Engineering and Physical Sciences Research Council. He has published over 160 manuscripts, is co-inventor of patents relating to nanomedicines and a co-founder of Tandem Nano Ltd.
Tânia Beatriz Creczynski-Pasa graduated in Pharmacy from the Federal University of Rio Grande do Sul (1986), she obtained her Master’s degree in Biological Chemistry at Federal University of Rio de Janeiro (1990) and her PhD in Biological Chemistry at Federal University of Rio de Janeiro (1994) with part of work at the University of Stuttgart (Germany). She is currently a full Professor at Federal University of Santa Catarina. She has experience in pharmacy and biochemistry, working mainly in the investigation of antitumor properties of new molecules and new strategies for cancer diagnosis. In parallel, she has been working in nanotechnology (especially in the development and analysis of siRNA carriers) and nanotoxicology. She has coordinated many projects, including the “Advanced diagnostic assessment for damage detection and determination of miRNAs as biomarkers for lung cancer”.
Marco Siccardi was appointed as a lecturer in Nanomedicine across the faculties of Health and Life Sciences and Science and Engineering at the University of Liverpool in 2012 and promoted to senior lecturer in Pharmacology in 2016. He has authored more than 80 peer reviewed publications, review manuscripts and book chapters. His research interests focus on the optimization of novel nanomedicine and traditional formulations for drug delivery based on experimental pharmacological data from in silico, in vitro and in vivo models, aiming to improve pharmacokinetics, efficacy and side effects. Additionally, he is interested in the clarification of the ADME processes involved in drug disposition and the identification of nanoformulation characteristics influencing drug exposure.
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have been identified as a promising material for biomedical applications. These include as contrast agents for medical imaging, drug delivery and/or cancer cell treatment. The nanotoxicological profile of SPIONs has been investigated in different studies and the distribution of SPIONs in the human body has not been fully characterized. The aim of this study was to develop a physiologically-based pharmacokinetic (PBPK) model to predict the pharmacokinetics of SPIONs. The distribution and accumulation of SPIONs in organs were simulated taking into consideration their penetration through capillary walls and their active uptake by specialized macrophages in the liver, spleen and lungs. To estimate the kinetics of SPION uptake, a novel experimental approach using primary macrophages was developed. The murine PBPK model was validated against in vivo pharmacokinetic data, and accurately described accumulation in liver, spleen and lungs. After validation of the murine model, a similar PBPK approach was developed to simulate the distribution of SPIONs in humans. These data demonstrate the utility of PBPK modeling for estimating biodistribution of inorganic nanoparticles and represents an initial platform to provide computational prediction of nanoparticle pharmacokinetics.
About the authors
Adny Henrique Silva obtained her PhD (2015) and her Master’s degree (2011) in Pharmacy from the Federal University of Santa Catarina, Florianópolis, Brazil. She is at present, a postdoctoral researcher in Biochemistry department of the same University. Her PhD research was on “evaluation of nanoparticles toxicity using in vitro, in vivo, ex vivo and in silico models”. During this period, she also had the opportunity to participate in other projects that were anticancer-related, including the gene modulation through siRNA delivery using nanocarriers. She is experienced in cell biology, biochemistry, toxicology and nanotechnology. She has been working for the past 7 years on the investigation of antitumor properties of new molecules and new strategies for cancer diagnosis as well as new strategies to study the toxicity of nanoparticles. She also had the opportunity of 10 months’ collaborative research at the University of Liverpool, England.
Enio Lima Jr works in the Centro Atómico Bariloche/CONICET, Argentina, as an independent researcher. He graduated in Physics and with a PhD in Physics of condensed matter at the Universidade Federal de Santa Catarina, Brazil, he has been working for more than 10 years in the study of magnetic nanoparticles and their applications.
Marcelo Vasquez Mansilla was born in Buenos Aires, Argentina in 1972. He received his Bachelor’s degree in Physics from Universidad Nacional de Cuyo, Argentina in 1997 and his PhD in Physics in 2004. He worked for 2 years at Istituto di Struttura della Materia del CNR di Roma and since 2007 he has held a position as a researcher at the Magnetic Resonance Laboratory in Centro Atomico Bariloche, Argentina. His current research focus on magnetism of nanostructure materials like magnetic nanoparticles and thin films. He is also involved in applied research using nanoparticles in medicine as magnetic hiperthermia, drug delivery and sensors.
Roberto Daniel Zysler obtained his MS degree in Physics in 1985 and in 1992 he obtained his PhD in Physics at the Instituto Balseiro (Universidad Nacional de Cuyo, Argentina). In 1995 he started a permanent research position as a scientific researcher (CONICET, Argentina) at the Magnetism Group of the Centro Atómico Bariloche (at the Magnetic Resonance Laboratory), and from this time he has worked on magnetic nanoparticles properties and their applications in bio-medicine. He is a Professor at the Instituto Balseior and advisor of Master’s degree thesis and PhD thesis for Physics candidates. He has over 150 scientific publication in international scientific journals and presented over 170 congress communication contributions at international scientific meetings.
Mary Luz Mojica Pisciotti obtained her PhD in Physics and her MSc in Medical Physics from Balseiro Institute and National University of Cuyo in Argentina and her BSc in Physics from the National University of Colombia. She is currently a postdoctoral researcher at the National Atomic Energy Commission (CNEA) in Bariloche. Her research is focused on the use of magnetic nanoparticles (MNPs) in medicine, particularly in magnetic hyperthermia and in the application of these nanomaterials in contrast-enhanced magnetic resonance imaging (MRI). Mary has had the opportunity of working on various aspects of MNPs, including synthesis, magnetic and non-magnetic properties characterization and heating mechanisms. Additionally she has performed physical and biological experiments with iron oxide MNPs in different systems, including cellular and animal models. Her background has allowed her to explore the potential of working with interdisciplinary teams.
Claudriana Locatelli obtained her PhD in Pharmacy in 2009. She is currently a Professor of Biochemistry at the University of the West of Santa Catarina (Unoesc). She contributes as a Professor at Unoesc Postgraduate Program of Bioscience and Health, and to the Program of Science and Biotechnology. She has experience in antioxidants of natural products and cancer treatment.
Rajith Kumar Reddy Rajoli graduated in Pharmacy from the Birla Institute of Technology and Science, Pilani (BITS-Pilani), India in 2009. Later, he received his MSc in drug delivery from University College London, UK in 2011 and in 2017 he obtained a PhD in Pharmacology from the University of Liverpool, Liverpool, UK. Following his PhD, he has been working as a research associate in the Molecular and Clinical Pharmacology department at the University of Liverpool. His current research focuses on informing the design of long-acting nanoparticles for intramuscular, subcutaneous and transdermal administration using physiologically based pharmacokinetic (PBPK) modeling.
Andrew Owen is Professor of Pharmacology at the University of Liverpool. He is Chair of the British Society for Nanomedicine, a Fellow of the Royal Society of Biology, and a Fellow of the British Pharmacological Society. His clinical and basic research focuses on understanding the mechanisms that underpin inter-patient variability in pharmacokinetics and pharmacodynamics, and to employ such knowledge to accelerate nanomedicine translation. His work is supported by the US Agency for International Development, the US National Institutes for Health, the UK Medical Research Council, the European Commission and the UK Engineering and Physical Sciences Research Council. He has published over 160 manuscripts, is co-inventor of patents relating to nanomedicines and a co-founder of Tandem Nano Ltd.
Tânia Beatriz Creczynski-Pasa graduated in Pharmacy from the Federal University of Rio Grande do Sul (1986), she obtained her Master’s degree in Biological Chemistry at Federal University of Rio de Janeiro (1990) and her PhD in Biological Chemistry at Federal University of Rio de Janeiro (1994) with part of work at the University of Stuttgart (Germany). She is currently a full Professor at Federal University of Santa Catarina. She has experience in pharmacy and biochemistry, working mainly in the investigation of antitumor properties of new molecules and new strategies for cancer diagnosis. In parallel, she has been working in nanotechnology (especially in the development and analysis of siRNA carriers) and nanotoxicology. She has coordinated many projects, including the “Advanced diagnostic assessment for damage detection and determination of miRNAs as biomarkers for lung cancer”.
Marco Siccardi was appointed as a lecturer in Nanomedicine across the faculties of Health and Life Sciences and Science and Engineering at the University of Liverpool in 2012 and promoted to senior lecturer in Pharmacology in 2016. He has authored more than 80 peer reviewed publications, review manuscripts and book chapters. His research interests focus on the optimization of novel nanomedicine and traditional formulations for drug delivery based on experimental pharmacological data from in silico, in vitro and in vivo models, aiming to improve pharmacokinetics, efficacy and side effects. Additionally, he is interested in the clarification of the ADME processes involved in drug disposition and the identification of nanoformulation characteristics influencing drug exposure.
Acknowledgments
This study was supported by doctoral fellowship from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), doctoral sandwich scholarship from Science Without Borders (Grant/Award Number: ‘BEX 0378/13-5’) (Ciências sem Fronteiras) and CPNq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and makes part of the doctoral activities of Adny Henrique Silva.
Conflict of interest statement: The authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
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- Biomimetic nanostructures for the silicone-biosystem interface: tuning oxygen-plasma treatments of polydimethylsiloxane
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Articles in the same Issue
- Frontmatter
- In this issue
- News
- CLINAM summit May 7–10, 2017
- Review
- Multifunctional graphene oxide for bioimaging: emphasis on biological research
- Mini Review
- The role of thromboxane A2 in complement activation-related pseudoallergy
- Original Articles
- Biomimetic nanostructures for the silicone-biosystem interface: tuning oxygen-plasma treatments of polydimethylsiloxane
- A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo
