Recommendation on the Use of Countercurrent Chromotography in Analytical Chemistry
IUPAC Projects
Recommendation on the Use of Countercurrent Chromotography in Analytical Chemistry
IUPAC has approved a two-year project to prepare a critical review of applications of countercurrent chromatography (CCC) in organic and inorganic analytical chemistry, pharmaceutical industry, and in radiochemistry. The project will place an emphasis on theory, methodology, and instrumentation. Recommendations will be made on the terminology and standardization, taking into account its relative position between other extraction and chromatography processes.
CCC is used as a method for the concentration, separation, and purification of chemical and pharmaceutical substances at both analytical and process (production) scales based on their partition between two immiscible solvent phases. One liquid phase is held stationary in the force field of a coil planet centrifuge while the other is eluted through it as the mobile phase. Among its various advantages is the ability to achieve high-resolution extractions/separations with minimal solvent use.
The application of CCC in analytical chemistry has been investigated for 16 years at a fundamental level at the Vernadsky Institute of Geochemistry and Analytical Chemistry at the Russian Academy of Sciences. Various applications of CCC to the concentration and separation of a number of elements in environmental and inorganic analysis (including the purification of chemical reagents) have been studied and a fundamental understanding of the hydrodynamics is developing. It is also clear that a basis for developing various methods of analysis has been established from the applications of CCC in the pharmaceutical industry, particularly in the production of drugs, and through the equipment made at the Brunel Institute of Bioengineering, UK, and at other research and development institutions.
The aim of this proposal is to survey emerging technologies and applications based on CCC, including the progress made in the pharmaceutical industry, radiochemistry, and analytical and through preparative-scale inorganic separations.
Comments from the chemistry community are welcome and should be addressed to the project coordinator Prof. B.Spivakov, Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin Str. 19, Moscow, Russia 119991, Tel.: +7 095 137 82 63, Fax: +7 095 938 20 54, E-mail: spivakov@geokhi.ru.
© 2014 by Walter de Gruyter GmbH & Co.
Articles in the same Issue
- Contents
- IUPAC and You
- IOCD: 20 Years of Building Capacity in Chemistry in Developing Countries
- Validated Analytical Methods–AOAC’s Experience Over 100 Years
- Small-Scale Chemistry
- The World Chemistry Congress 2001 and the Young Scientist Awards
- Relocating to Cyberspace
- Erick Carreira Receives the Thieme–IUPAC Prize
- Roger Atkinson Receives the ACS Award for Creative Advances in Environmental Science and Technology
- Standard Potentials of Radicals
- Glossary for Toxicokinetics of Chemicals
- Recommendation on the Use of Countercurrent Chromotography in Analytical Chemistry
- Nomenclature for Rotaxanes, Catenanes, and Macromolecular Rotaxanes
- IUPAC Seeks Your Comments
- Thermochemistry of Chemical Reactions: Terminology, Symbols, and Experimental Methods for the Determination of Bond Energies
- Guidelines for the Representation of Pulse Sequences for Solution-State Nuclear Magnetic Resonance Spectrometry (IUPAC Recommendations 2001)
- JCAMP-DX. A Standard Format for the Exchange of Ion Mobility Spectrometry Data (IUPAC Recommendations 2001)
- Molality-Based Primary Standards of Electrolytic Conductivity (IUPAC Technical Report)
- NMR Nomenclature. Nuclear Spin Properties and Conventions for Chemical Shifts (IUPAC Recommendations 2001)
- Electrochemistry and Interfacial Chemistry for the Environment
- Handbook of Pharmaceutical Salts: Properties, Selection, and Use
- Green Chemistry–the Japanese translation of the special topic issue of Pure and Applied Chemistry (Vol. 72, No. 7, 2000)
- Polymer Characterization and Materials Science
- Non-Metals in Liquid Alkali Metals
- Heat Capacity of Liquids: Critical Review and Recommended Values
- Pesticide Formulation and Application Systems: A New Century For Agricultural Formulations
- Advanced Materials
- Solution Chemistry
- Organometallic Chemistry Directed Towards Organic Synthesis
- 35th International Conference on Coordination Chemistry (35-ICCC) 21–26 July 2002, Heidelberg, Germany
- The Second Pan-European Younger Chemists’ Conference 30 September–2 October 2002, Heidelberg, Germany
- 10th International Symposium on Macromolecule Metal Complexes (MMC-X) 20–24 May 2003, Moscow, Russia
- Plutonium Futures–The Science 2003 6–10 July 2003, Albuquerque, New Mexico, USA
- Conference Announcements in Brief
- Calendar of IUPAC Sponsored Conferences
Articles in the same Issue
- Contents
- IUPAC and You
- IOCD: 20 Years of Building Capacity in Chemistry in Developing Countries
- Validated Analytical Methods–AOAC’s Experience Over 100 Years
- Small-Scale Chemistry
- The World Chemistry Congress 2001 and the Young Scientist Awards
- Relocating to Cyberspace
- Erick Carreira Receives the Thieme–IUPAC Prize
- Roger Atkinson Receives the ACS Award for Creative Advances in Environmental Science and Technology
- Standard Potentials of Radicals
- Glossary for Toxicokinetics of Chemicals
- Recommendation on the Use of Countercurrent Chromotography in Analytical Chemistry
- Nomenclature for Rotaxanes, Catenanes, and Macromolecular Rotaxanes
- IUPAC Seeks Your Comments
- Thermochemistry of Chemical Reactions: Terminology, Symbols, and Experimental Methods for the Determination of Bond Energies
- Guidelines for the Representation of Pulse Sequences for Solution-State Nuclear Magnetic Resonance Spectrometry (IUPAC Recommendations 2001)
- JCAMP-DX. A Standard Format for the Exchange of Ion Mobility Spectrometry Data (IUPAC Recommendations 2001)
- Molality-Based Primary Standards of Electrolytic Conductivity (IUPAC Technical Report)
- NMR Nomenclature. Nuclear Spin Properties and Conventions for Chemical Shifts (IUPAC Recommendations 2001)
- Electrochemistry and Interfacial Chemistry for the Environment
- Handbook of Pharmaceutical Salts: Properties, Selection, and Use
- Green Chemistry–the Japanese translation of the special topic issue of Pure and Applied Chemistry (Vol. 72, No. 7, 2000)
- Polymer Characterization and Materials Science
- Non-Metals in Liquid Alkali Metals
- Heat Capacity of Liquids: Critical Review and Recommended Values
- Pesticide Formulation and Application Systems: A New Century For Agricultural Formulations
- Advanced Materials
- Solution Chemistry
- Organometallic Chemistry Directed Towards Organic Synthesis
- 35th International Conference on Coordination Chemistry (35-ICCC) 21–26 July 2002, Heidelberg, Germany
- The Second Pan-European Younger Chemists’ Conference 30 September–2 October 2002, Heidelberg, Germany
- 10th International Symposium on Macromolecule Metal Complexes (MMC-X) 20–24 May 2003, Moscow, Russia
- Plutonium Futures–The Science 2003 6–10 July 2003, Albuquerque, New Mexico, USA
- Conference Announcements in Brief
- Calendar of IUPAC Sponsored Conferences
