Characterization of Compounds in Solution: Theory and Practice
New Books and Publications
Characterization of Compounds in Solution: Theory and Practice
William H. Streng, Kluwer Academic/Plenum Publishers, New York, 2001. (ISBN 3-306-46595-7)
The purpose of this book is to discuss concisely and comprehensively solution properties of compounds that are most important in the area of pharmaceutics. While there are many topics that can be included in a discussion on solution properties of compounds, the following are the most critical in the area of pharmaceutics: equilibrium constants, partition efficients, general solubility, solubility in protic solvents, and solution stability. The ambitious concept of this book is to bring together these topics in a logical and concise manner.
After an introductory chapter on compound characterization, the theoretical chapters of Streng's book cover thermodynamics, kinetics, equilibrium constants, partition coefficient, solubility, solubility of weak acids and bases, solution stability, and instrumentation.
Clearly, most of these chapters could easily fill a volume in itself, but the truly original idea of the book is the self-sufficient description of theory and practice used for characterizing compounds in solution. The remaining chapters cover procedures and examples for the practical investigation of equilibria, partitioning, solubility, and solution kinetics.
The strength of this book lies in the chapters on instrumentation and solution kinetics. Here the author draws from his scientific experience and convincingly shows how a general knowledge in physical chemistry is applied to obtain experimentally reliable information and theoretically sound interpretations.
The digressions in some of the introductory remarks of the individual chapters are doubtless a matter of taste. For example, the comparison of chemical kinetics with a road between two cities that are separated by a small or a tall mountain seems—from the reviewer's point of view—a bit too simplistic.
In addition, some misleading statements in the theoretical chapters should be eliminated in the next edition. For example, in one section a catalyst is described as "shifting the equilibrium to the right." However, catalysts increase the rate at which equilibrium is attained, but do not effect its position.
To summarize, it can be said that Streng's book covers compactly a wide variety of theoretical and practical aspects of characterizing compounds of pharmaceutical relevance using physicochemical methods. It will be most beneficial to readers who plan to set up their own experimental investigations to characterize compounds in solution.
Reviewed by Heinz Gamsjäger, Montanuniversität Leoben, Austria.
© 2014 by Walter de Gruyter GmbH & Co.
Articles in the same Issue
- Masthead
- Contents
- Broadening Active Participation in IUPAC Activities
- If IUPAC is to be successful in representing worldwide chemistry, it needs to foster synergistic relationships with the global community of chemists.
- The Bureau International des Poids et Mesures: Establishing Standards in the Physical Sciences
- The kilogram is, today, the only base unit still defined in terms of a material artifact
- The Synthesis and Naming of Elements 110 and Beyond
- Reliable Solubility Data in the Age of Computerized Chemistry: Why, How, and When?
- Modeling, regardless of the discipline, has one common feature: Reliable data are an essential element.
- Breaking Away from the Old Three Ss
- Young Chemists Travel Far with Canadian National Committee Awards
- Chemical Nomenclature and Structure Representation
- Nomenclature of Inorganic Chemistry
- SCOPE/IUPAC International Symposium on Endocrine Active Substances
- Generic Source-Based Nomenclature for Polymers (IUPAC Recommendations 2001)
- Quantum Chemical B3LYP/cc-pvqz Computation of Ground-State Structures and Properties of Small Molecules with Atoms of Z ≤ 18 (Hydrogen to Argon) (IUPAC Technical Report)
- Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
- Critical Evaluation of Stability Constants of Phosphonic Acids (IUPAC Technical Report)
- IUPAC Seeks Your Comments
- Quantities, Terminology, and Symbols in Photothermal and Related Spectroscopies
- The Naming of New Elements
- The Biogeochemistry of Iron in Seawater
- Polymerization Processes and Polymer Materials, Volumes I and II
- Characterization of Compounds in Solution: Theory and Practice
- CRC Handbook of Optical Resolutions via Diastereomeric Salt Formation
- Medicinal Chemistry
- Analytical Sciences
- CAS/IUPAC Conference on Chemical Identifiers and XML for Chemistry 1 July 2002, Columbus, Ohio, USA
- Central European Conference on “Chemistry Towards Biology” 8-12 September 2002, Portoroz, Slovenia
- The Ninth International Conference on Flow Analysis 10-14 February 2003, Geelong, Victoria, Australia
- Conference Announcements in Brief
- Calendar of IUPAC Sponsored Conferences
Articles in the same Issue
- Masthead
- Contents
- Broadening Active Participation in IUPAC Activities
- If IUPAC is to be successful in representing worldwide chemistry, it needs to foster synergistic relationships with the global community of chemists.
- The Bureau International des Poids et Mesures: Establishing Standards in the Physical Sciences
- The kilogram is, today, the only base unit still defined in terms of a material artifact
- The Synthesis and Naming of Elements 110 and Beyond
- Reliable Solubility Data in the Age of Computerized Chemistry: Why, How, and When?
- Modeling, regardless of the discipline, has one common feature: Reliable data are an essential element.
- Breaking Away from the Old Three Ss
- Young Chemists Travel Far with Canadian National Committee Awards
- Chemical Nomenclature and Structure Representation
- Nomenclature of Inorganic Chemistry
- SCOPE/IUPAC International Symposium on Endocrine Active Substances
- Generic Source-Based Nomenclature for Polymers (IUPAC Recommendations 2001)
- Quantum Chemical B3LYP/cc-pvqz Computation of Ground-State Structures and Properties of Small Molecules with Atoms of Z ≤ 18 (Hydrogen to Argon) (IUPAC Technical Report)
- Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
- Critical Evaluation of Stability Constants of Phosphonic Acids (IUPAC Technical Report)
- IUPAC Seeks Your Comments
- Quantities, Terminology, and Symbols in Photothermal and Related Spectroscopies
- The Naming of New Elements
- The Biogeochemistry of Iron in Seawater
- Polymerization Processes and Polymer Materials, Volumes I and II
- Characterization of Compounds in Solution: Theory and Practice
- CRC Handbook of Optical Resolutions via Diastereomeric Salt Formation
- Medicinal Chemistry
- Analytical Sciences
- CAS/IUPAC Conference on Chemical Identifiers and XML for Chemistry 1 July 2002, Columbus, Ohio, USA
- Central European Conference on “Chemistry Towards Biology” 8-12 September 2002, Portoroz, Slovenia
- The Ninth International Conference on Flow Analysis 10-14 February 2003, Geelong, Victoria, Australia
- Conference Announcements in Brief
- Calendar of IUPAC Sponsored Conferences
