Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
Highlights from Pure and Applied Chemistry
Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
by Ingemar Wadsö and Robert N. Goldberg
Pure and Applied Chemistry Vol. 73, No. 10, pp. 1625-1639 (2001)
Isothermal microcalorimetric techniques have been much improved during the past decades, and several types of instruments are commercially available. Application areas include, for example, ligand binding studies, dissolution and sorption measurements, estimation of the stability of chemical substances and technical products, and measurements of metabolic reactions in living cellular systems.
Most isothermal microcalorimeters are calibrated by the release of heat in an electrical heater positioned in the calorimetric vessel or in its close proximity. However, in some cases it is difficult to conduct electrical calibration experiments, which will closely mimic the heat flow pattern of the process or reaction under investigation. This can lead to a significant error in the calibration value and, in some cases, the use of some chemical calibration would therefore be preferable. Regardless of which calibration technique is used, it is often desirable to quantitatively control the overall performance of an instrument by use of a suitable test reaction. Simple and reliable test reactions are also very suitable for the training of experimenters. In order to allow a close comparison between results from chemical calibrations or test experiments and results from a calorimetric investigation, it is important to have many different chemical calibration and test reactions available.
In this report, guidelines are presented on the use of standardized chemical test and calibration reactions suitable for use in different areas of isothermal microcalorimetry. The focus is on reactions suitable for use under ambient conditions. Further, a standardized terminology in describing the characteristics of isothermal microcalorimeters is proposed. “Nanocalorimeters,” usually indicating calorimeters with a detection limit approaching the nanowatt range, are in this report not distinguished from “microcalorimeters.”
The Task Group responsible for the project was: I. Wadsö (Chairman), A. E. Beezer, R. N. Goldberg, G. Olofsson, K. Murphy, J. Rouquerol and J. Sipowska.
<http://www.iupac.org/publications/pac/2001/7310/7310x1625.html>
© 2014 by Walter de Gruyter GmbH & Co.
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- Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
- Critical Evaluation of Stability Constants of Phosphonic Acids (IUPAC Technical Report)
- IUPAC Seeks Your Comments
- Quantities, Terminology, and Symbols in Photothermal and Related Spectroscopies
- The Naming of New Elements
- The Biogeochemistry of Iron in Seawater
- Polymerization Processes and Polymer Materials, Volumes I and II
- Characterization of Compounds in Solution: Theory and Practice
- CRC Handbook of Optical Resolutions via Diastereomeric Salt Formation
- Medicinal Chemistry
- Analytical Sciences
- CAS/IUPAC Conference on Chemical Identifiers and XML for Chemistry 1 July 2002, Columbus, Ohio, USA
- Central European Conference on “Chemistry Towards Biology” 8-12 September 2002, Portoroz, Slovenia
- The Ninth International Conference on Flow Analysis 10-14 February 2003, Geelong, Victoria, Australia
- Conference Announcements in Brief
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Articles in the same Issue
- Masthead
- Contents
- Broadening Active Participation in IUPAC Activities
- If IUPAC is to be successful in representing worldwide chemistry, it needs to foster synergistic relationships with the global community of chemists.
- The Bureau International des Poids et Mesures: Establishing Standards in the Physical Sciences
- The kilogram is, today, the only base unit still defined in terms of a material artifact
- The Synthesis and Naming of Elements 110 and Beyond
- Reliable Solubility Data in the Age of Computerized Chemistry: Why, How, and When?
- Modeling, regardless of the discipline, has one common feature: Reliable data are an essential element.
- Breaking Away from the Old Three Ss
- Young Chemists Travel Far with Canadian National Committee Awards
- Chemical Nomenclature and Structure Representation
- Nomenclature of Inorganic Chemistry
- SCOPE/IUPAC International Symposium on Endocrine Active Substances
- Generic Source-Based Nomenclature for Polymers (IUPAC Recommendations 2001)
- Quantum Chemical B3LYP/cc-pvqz Computation of Ground-State Structures and Properties of Small Molecules with Atoms of Z ≤ 18 (Hydrogen to Argon) (IUPAC Technical Report)
- Standards in Isothermal Microcalorimetry (IUPAC Technical Report)
- Critical Evaluation of Stability Constants of Phosphonic Acids (IUPAC Technical Report)
- IUPAC Seeks Your Comments
- Quantities, Terminology, and Symbols in Photothermal and Related Spectroscopies
- The Naming of New Elements
- The Biogeochemistry of Iron in Seawater
- Polymerization Processes and Polymer Materials, Volumes I and II
- Characterization of Compounds in Solution: Theory and Practice
- CRC Handbook of Optical Resolutions via Diastereomeric Salt Formation
- Medicinal Chemistry
- Analytical Sciences
- CAS/IUPAC Conference on Chemical Identifiers and XML for Chemistry 1 July 2002, Columbus, Ohio, USA
- Central European Conference on “Chemistry Towards Biology” 8-12 September 2002, Portoroz, Slovenia
- The Ninth International Conference on Flow Analysis 10-14 February 2003, Geelong, Victoria, Australia
- Conference Announcements in Brief
- Calendar of IUPAC Sponsored Conferences
