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Cloud point extraction of disulfiram for its HPLC-MS/MS determination in synthetic urine

  • Volodymyr O. Doroschuk EMAIL logo , Anastasiya B. Grogul , Yevhen S. Mandzyuk , Oksana G. Makukha und Nataliya O. Grytsyk
Veröffentlicht/Copyright: 25. Juni 2016
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Chemical Papers
Aus der Zeitschrift Chemical Papers Band 70 Heft 10

Abstract

A new simple cloud point extraction/preconcentration method was developed for the HPLC-MS/MS determination of disulfiram in synthetic urine. Some parameters with an effect on the extraction, such as the concentration of Triton X-114, pH influence, incubation time, equilibration temperature and centrifuging parameters, were studied and optimised. The method proposed for the HPLC-MS/MS determination of disulfiram in synthetic urine with preliminary cloud point extraction was validated. The calibration curve was linear in the range of 0.025-15.4 ng mL–1 . The limits of detection (3σ) and quantification (10σ) were 0.008 ng mL–1 and 0.025 ng mL–1, respectively. The matrix effect (96 %), recovery of the extraction procedure (95 %) and overall “process efficiency” (91 %) were also estimated. The results show that the sensitivity, metrological characteristics, ecological safety, simplicity and convenience of the suggested procedure exceed its analogues based on extraction using organic solvents.

Keywords: cloud point extraction; disulfiram determination; non-ionic surfactant

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Received: 2015-12-21
Revised: 2016-3-10
Accepted: 2016-3-11
Published Online: 2016-6-25
Published in Print: 2016-10-1

© 2016 Institute of Chemistry, Slovak Academy of Sciences

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https://doi.org/10.1515/chempap-2016-0074
Schlagwörter für diesen Artikel
cloud point extraction; disulfiram determination; non-ionic surfactant

Artikel in diesem Heft

  1. Original Paper
  2. Simultaneous analysis of polar and non-polar components of cell membrane phospholipids by GC-MS
  3. Original Paper
  4. Cloud point extraction of disulfiram for its HPLC-MS/MS determination in synthetic urine
  5. Original Paper
  6. Revealing the seed proteome of the health benefitting grain amaranth (Amaranthus cruentus L.)
  7. Original Paper
  8. Possible role of hydrolytic enzymes (Sap, Kex2) in Candida albicans response to aromatic compounds bearing a sulfone moiety
  9. Original Paper
  10. Using nutritional and oxidative stress to increase content of healthbeneficial fatty acids in oleaginous and non-oleaginous yeasts
  11. Original Paper
  12. Fatty acids and amino acids of entomopathogenic fungus Conidiobolus coronatus grown on minimal and rich media
  13. Original Paper
  14. Promotional effect of cobalt addition on catalytic performance of Ce0.5Zr0.5O2 mixed oxide for diesel soot combustion
  15. Original Paper
  16. Microwave-assisted continuous reactive distillation process for preparation of ethyl acetate
  17. Original Paper
  18. Wall-retardation effects on particles settling through non-Newtonian fluids in parallel plates
  19. Original Paper
  20. Microwave-assisted decomposition of fgd gypsum in the presence of magnetite and anthracite
  21. Original Paper
  22. Effect of PHB on the properties of biodegradable PLA blends
  23. Original Paper
  24. Thiophene-free diphenyl-amino-stilbene-diketo-pyrrolo-pyrrole derivatives as donors for organic bulk heterojunction solar cells
  25. Short Communication
  26. UV-induced reduction of Ag+ by diazene sulphonates: new method of metallisation of surfaces
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