Startseite Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation
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Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

  • Da-Wei Zhang , Yu-Min Zhang , Yi-Liang Zhang , Tian-Qi Zhao , Hong-Wei Liu , Yuan-Ming Gan und Qiang Gu EMAIL logo
Veröffentlicht/Copyright: 30. Dezember 2014
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Abstract

An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

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Received: 2014-4-29
Revised: 2014-7-14
Accepted: 2014-8-3
Published Online: 2014-12-30
Published in Print: 2015-3-1

© 2015 Institute of Chemistry, Slovak Academy of Sciences

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