Flavonoids inhibiting glycation of bovine serum albumin: affinity–activity relationship
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Abstract
Protein glycation leads to the formation of advanced glycation end-products (AGEs), which contribute to the pathogenesis of diabetic complications. The structure-activity relationship of dietary flavonoids for inhibiting the glycation of bovine serum albumin (BSA) in vitro was subjected to a detailed investigation. The structure-activity relationship revealed that: 1) the hydroxylation on ring B of the flavones enhanced the inhibition and the hydroxyl groups at the C-5 and C-7 positions of flavones favoured the inhibition; 2) the optimal number of hydroxyl groups on ring B of the flavonols was one (at the C-3 position) and the methylation of flavonols weakened the inhibition; 3) the methoxylation at the C-6 position and methylation at C-4' position of genistein clearly enhanced the inhibition; 4) the hydroxyl groups at the C-5 and C-7 positions of flavanones were in favour of the inhibition; 5) the glycosylation of flavonoids significantly weakened the inhibition. Obvious linear affinity-activity relationships exist between the BSA-flavonoid interaction and flavonoids as BSA glycation inhibitors (R2 = 0.76585). The flavonoids with a higher affinity to BSA exhibited a stronger inhibition of the glycation of BSA.
References
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© 2015 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- One-step preparation of porous copper nanowires electrode for highly sensitive and stable amperometric detection of glyphosate
- Classification of wine distillates using multivariate statistical methods based on their direct GC-MS analysis
- Determination of cigarette papers moisture content by gas chromatography
- Flavonoids inhibiting glycation of bovine serum albumin: affinity–activity relationship
- Treatment of natural rubber latex serum waste by co-digestion with macroalgae, Chaetomorpha sp. and Ulva intestinalis, for sustainable production of biogas
- Physicochemical aspects of Trichosporon cutaneum CCY 30-5-10 adhesion and biofilm formation potential on cellophane
- Immobilisation of Aspergillus oryzae α-amylase and Aspergillus niger glucoamylase enzymes as cross-linked enzyme aggregates
- Dissolution kinetics of cerussite in an alternative leaching reagent for lead
- Preparation of quaternary pyridinium salts as possible proton conductors
- Stable UV absorption material synthesized by intercalation of squaric acid anion into layered double hydroxides
- Electrolytic preparation of nanosized Cu/Ni–Cu multilayered coatings
- Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation
- Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent
- Practical synthesis of 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone
- Conversion of phenylacetonitrile in supercritical alcohols within a system containing small volume of water
