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Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia
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Gergely Toldi
Published/Copyright:
July 4, 2011
Abstract
Background: Preeclampsia is characterized by a maternal systemic inflammatory response and the impairment of maternal immune tolerance present in healthy pregnancy. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the monitoring of systemic inflammation. We aimed to assess the levels of suPAR and other markers of systemic inflammation in preeclampsia compared to healthy pregnancy.
Methods: We determined plasma suPAR, IL-6 and high sensitivity C-reactive protein (hs-CRP) levels in plasma samples of 62 healthy pregnant and 41 preeclamptic women in the third trimester of pregnancy.
Results: Plasma suPAR levels were elevated in preeclampsia [3.18 (2.30–4.71) ng/mL vs. 2.02 (1.81–2.40) ng/mL, p=0.0001, median (interquartile range)]. IL-6 and hs-CRP levels were also higher compared with healthy pregnancy [5.99 (2.97–18.12) pg/mL vs. 1.41 (1.00–2.70) pg/mL, p=0.0001 and 6.60 (3.55–15.40) mg/L vs. 3.90 (2.10–7.25) mg/L, p=0.006, respectively, median (interquartile range)]. Linear regression analyses revealed an association between individual plasma suPAR and log IL-6 levels as well as log hs-CRP levels.
Conclusions: suPAR levels are elevated in preeclampsia and vary in a narrower range compared with IL-6 and hs-CRP. ROC analysis indicated that monitoring of suPAR levels is a suitable tool for the detection of systemic inflammation in pregnancy.
Received: 2011-4-29
Accepted: 2011-5-23
Published Online: 2011-07-4
Published in Print: 2011-11-01
©2011 by Walter de Gruyter Berlin Boston
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- Oxidative stress and diabetes mellitus
- Human papilloma virus (HPV) molecular diagnostics
- Opinion Papers
- Urine immunofixation electrophoresis remains important and is complementary to serum free light chain
- Permissible performance limits of regression analyses in method comparisons
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