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Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications
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Alexandra Dorn-Beineke
Veröffentlicht/Copyright:
1. Juni 2005
Abstract
We review the current knowledge of the pathophysiology of sickle cell disease (SCD), the clinical complications and the state of the art in SCD diagnostics. Today, a flexible laboratory concept allows the fast and economic clarification of the patients' sickle cell hemoglobin (HbS) status, e.g. additional compound heterozygosities. In contrast to a well-investigated pathophysiology of the disease, factors influencing the severity of symptoms as well as some laboratory findings in SCD still lack a final explanation. In this review, we focus on red cell lysis resistance as an additional diagnostic tool in SCD. There is a need for further studies regarding lysis resistance in blood samples from patients with HbS.
:
Published Online: 2005-06-01
Published in Print: 2002-12-02
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications
- Family Studies: Their Role in the Evaluation of Genetic Cardiovascular Risk Factors
- Polymorphisms in the Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Patients with Myocardial Infarction
- Effect of S-(1,2-Dicarboxyethyl) Glutathione and S-(1,2-Dicarboxyethyl) Cysteine on the Stimulus-Induced Superoxide Generation and Tyrosyl Phosphorylation of Proteins in Human Neutrophils
- Hyperhomocysteinemia Is Related to a Decreased Blood Level of Vitamin B12 in the Second and Third Trimester of Normal Pregnancy
- Frequencies of Q188R and N314D Mutations and IVS5-24G>A Intron Variation in the Galactose-1-Phosphate Uridyl Transferase (GALT) Gene in the Slovenian Population
- Umbilical Cord and Maternal Blood Leptin Concentrations in Intrauterine Growth Retardation
- Blood Concentrations of Selenium, Zinc, Iron, Copper and Calcium in Patients with Hepatocellular Carcinoma
- TaqMan Systems for Genotyping of Disease-Related Polymorphisms Present in the Gene Encoding Apolipoprotein E
- Antioxidant Status in Thyroid Dysfunction
- Diagnostic Efficiency of Cystatin C and Serum Creatinine as Markers of Reduced Glomerular Filtration Rate in the Elderly
- Comparing Different Methods for Homocysteine Determination
- Classification of Renal Proteinuria: A Simple Algorithm
- Reference Ranges for Serum Concentrations of Lutropin (LH), Follitropin (FSH), Estradiol (E2), Prolactin, Progesterone, Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone Sulfate (DHEAS), Cortisol and Ferritin in Neonates, Children and Young Adults
- Validation of a Kinetic Model for the Reactions in RIA
- Automated Counting of Cells in Cerebrospinal Fluid Using the CellDyn-4000 Haematology Analyser
- Urine Trans,trans-muconic Acid Levels in Residents of a Business Area of Bangkok, Thailand
- Hemoglobin Electrophoresis in Thai Non-Anemic Pregnant Subjects, a Need for Additional Screening for Hemoglobin E
- Meetings and Awards
Artikel in diesem Heft
- Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications
- Family Studies: Their Role in the Evaluation of Genetic Cardiovascular Risk Factors
- Polymorphisms in the Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Patients with Myocardial Infarction
- Effect of S-(1,2-Dicarboxyethyl) Glutathione and S-(1,2-Dicarboxyethyl) Cysteine on the Stimulus-Induced Superoxide Generation and Tyrosyl Phosphorylation of Proteins in Human Neutrophils
- Hyperhomocysteinemia Is Related to a Decreased Blood Level of Vitamin B12 in the Second and Third Trimester of Normal Pregnancy
- Frequencies of Q188R and N314D Mutations and IVS5-24G>A Intron Variation in the Galactose-1-Phosphate Uridyl Transferase (GALT) Gene in the Slovenian Population
- Umbilical Cord and Maternal Blood Leptin Concentrations in Intrauterine Growth Retardation
- Blood Concentrations of Selenium, Zinc, Iron, Copper and Calcium in Patients with Hepatocellular Carcinoma
- TaqMan Systems for Genotyping of Disease-Related Polymorphisms Present in the Gene Encoding Apolipoprotein E
- Antioxidant Status in Thyroid Dysfunction
- Diagnostic Efficiency of Cystatin C and Serum Creatinine as Markers of Reduced Glomerular Filtration Rate in the Elderly
- Comparing Different Methods for Homocysteine Determination
- Classification of Renal Proteinuria: A Simple Algorithm
- Reference Ranges for Serum Concentrations of Lutropin (LH), Follitropin (FSH), Estradiol (E2), Prolactin, Progesterone, Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone Sulfate (DHEAS), Cortisol and Ferritin in Neonates, Children and Young Adults
- Validation of a Kinetic Model for the Reactions in RIA
- Automated Counting of Cells in Cerebrospinal Fluid Using the CellDyn-4000 Haematology Analyser
- Urine Trans,trans-muconic Acid Levels in Residents of a Business Area of Bangkok, Thailand
- Hemoglobin Electrophoresis in Thai Non-Anemic Pregnant Subjects, a Need for Additional Screening for Hemoglobin E
- Meetings and Awards
