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Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications
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Alexandra Dorn-Beineke
Published/Copyright:
June 1, 2005
Abstract
We review the current knowledge of the pathophysiology of sickle cell disease (SCD), the clinical complications and the state of the art in SCD diagnostics. Today, a flexible laboratory concept allows the fast and economic clarification of the patients' sickle cell hemoglobin (HbS) status, e.g. additional compound heterozygosities. In contrast to a well-investigated pathophysiology of the disease, factors influencing the severity of symptoms as well as some laboratory findings in SCD still lack a final explanation. In this review, we focus on red cell lysis resistance as an additional diagnostic tool in SCD. There is a need for further studies regarding lysis resistance in blood samples from patients with HbS.
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Published Online: 2005-06-01
Published in Print: 2002-12-02
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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