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Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis

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Published/Copyright: December 5, 2013
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 52 Issue 5

Abstract

Background: The aim of the article was to systematically review published data about the relationship between prostate-specific antigen (PSA) kinetics, including PSA doubling time (PSAdt) and PSA velocity (PSAvel), and detection rate (DR) of positron emission tomography/computed tomography (PET/CT) using radiolabelled choline in restaging prostate cancer (PCa).

Methods: A comprehensive literature search of studies published through July 2013 regarding the relationship between PSA kinetics and DR of radiolabelled choline PET/CT was carried out. Furthermore, a meta-analysis was performed in order to establish the DR of radiolabelled choline PET/CT using different cut-off values of PSAdt (≤ or >6 months) and PSAvel [>1 or ≤1 ng/(mL year) and >2 or ≤2 ng/(mL year)]. Moreover, a pooled analysis to establish whether PSAdt and PSAvel (using the abovementioned cut-off values) may predict positive PET/CT results was carried out.

Results: Fourteen articles were selected. The pooled DR of radiolabelled choline PET/CT in restaging PCa was 58% [95% confidence interval (CI) 55–60]. Most articles reported a relationship between PSA kinetics and DR of PET/CT. Pooled DR of radiolabelled choline PET/CT increased to 65% (95% CI 58–71) when PSAdt was ≤6 months and to 71% (95% CI 66–76) and 77% (95% CI 71–82) when PSAvel was >1 or >2 ng/(mL year), respectively. PSAdt ≤6 months and PSAvel >1 or >2 ng/(mL year) proved to be relevant factors in predicting the positive result of radiolabelled choline PET/CT.

Conclusions: Due to the strong relationship between PSA kinetics and DR of radiolabelled choline PET/CT, beyond PSA values, PSAdt and PSAvel should be taken into account in the selection of PCa patients who should undergo radiolabelled choline PET/CT for restaging.

Keywords: choline; positron emission tomography; prostate cancer; prostate-specific antigen (PSA); PSA kinetics
Corresponding author: Luca Giovanella, PD, MD, Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Via Ospedale, 12, 6500, Bellinzona, Switzerland, Phone: +41 9181186 72, Fax +41 918118250, E-mail:

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Received: 2013-8-21
Accepted: 2013-11-4
Published Online: 2013-12-5
Published in Print: 2014-5-1

©2014 by Walter de Gruyter Berlin/Boston

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https://doi.org/10.1515/cclm-2013-0675
Keywords for this article
choline; positron emission tomography; prostate cancer; prostate-specific antigen (PSA); PSA kinetics

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Potential application of fetal epigenetic markers on the non-invasive prenatal detection of chromosomal abnormality
  4. Review
  5. Epigenetic mechanisms in bone
  6. Opinion Papers
  7. Circulating fetal cell-free DNA and prenatal molecular diagnostics: are we ready for consensus?
  8. Hepcidin levels in chronic hemodialysis patients: a critical evaluation
  9. D-dimer testing for suspected venous thromboembolism in the emergency department. Consensus document of AcEMC, CISMEL, SIBioC, and SIMeL
  10. General Clinical Chemistry and Laboratory Medicine
  11. Effect of biobanking conditions on short-term stability of biomarkers in human serum and plasma
  12. Non-invasive detection of fetal trisomy 21 using fetal epigenetic biomarkers with a high CpG density
  13. Development and validation of dried matrix spot sampling for the quantitative determination of amyloid β peptides in cerebrospinal fluid
  14. Instability of cerebrospinal fluid after delayed storage and repeated freezing: a holistic study by drop coating deposition Raman spectroscopy
  15. Analysis of patients with γ-heavy chain disease by the heavy/light chain and free light chain assays
  16. Performance of urinary NGAL and L-FABP in predicting acute kidney injury and subsequent renal recovery: a cohort study based on major surgeries
  17. Rapid extraction, identification and quantification of drugs of abuse in hair by immunoassay and ultra-performance liquid chromatography tandem mass spectrometry
  18. Validity and reliability of the 13C-methionine breath test for the detection of moderate hyperhomocysteinemia in Mexican adults
  19. Quantitative detection of target cells using unghosted cells (UGCs) of DxH 800 (Beckman Coulter)
  20. Evaluation of different sized blood sampling tubes for thromboelastometry, platelet function, and platelet count
  21. Cancer Diagnostics
  22. Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations
  23. Analytical performance of a new one-step quantitative prostate-specific antigen assay, the FREND™ PSA Plus
  24. Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis
  25. Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival
  26. Cardiovascular Diseases
  27. Red blood cell distribution width predicts survival in patients with Eisenmenger syndrome
  28. Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients
  29. Corrigendum
  30. Standardization and analytical goals for glycated hemoglobin measurement
  31. Letter to the Editors
  32. Do we need to worry about contamination by circulating fetal DNA?
  33. Stat testing utilization in clinical laboratories. National survey of Italian Society of Clinical Biochemistry and Molecular Biology (SIBioC)
  34. Aldosterone measurement with LiaisonXL automated system: remarks about reference range
  35. Better blood collection tubes for plasma glucose: ready for prime time?
  36. Upregulation of cytokines and IL-17 in patients with hereditary angioedema
  37. Underestimation of platelet count on magnesium salt-anticoagulated samples
  38. Extensive elevation of BNP but not NT-ProBNP in a patient with advanced urothelial carcinoma in absence of cardiac failure and volume overload
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