Do we really need high-sensitive troponin immunoassays in the emergency department? Definitely, yes!
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Karl J. Lackner
Abstract
Cardiac troponins have changed our understanding of myocardial infarction profoundly during the past 20 years. In fact release of cardiac troponin into the blood has become part of the definition of myocardial infarction. Diagnostics and treatment have taken these new insights into account. The novel high-sensitive assays for cardiac troponins that are available recently clearly constitute a significant further improvement of analytical performance. In addition, the still incomplete clinical data available indicate that these assays will also further improve patient care in many ways. In summary, cardiac troponins are a great example of the potential impact of analytical performance of diagnostic tests on patient care and patient outcome.
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©2014 by Walter de Gruyter Berlin Boston
Articles in the same Issue
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- The ten commandments of laboratory testing for emergency physicians
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- Critical role of RAGE in lung physiology and tumorigenesis: a potential target of therapeutic intervention?
- Opinion Papers
- Do we really need high-sensitive troponin immunoassays in the emergency department? Definitely, yes!
- Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not
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Articles in the same Issue
- Frontmatter
- Editorial
- The ten commandments of laboratory testing for emergency physicians
- Review
- Critical role of RAGE in lung physiology and tumorigenesis: a potential target of therapeutic intervention?
- Opinion Papers
- Do we really need high-sensitive troponin immunoassays in the emergency department? Definitely, yes!
- Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not
- General Clinical Chemistry and Laboratory Medicine
- Cortisol and cortisone ratio in urine: LC-MS/MS method validation and preliminary clinical application
- Urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion increases in normal pregnancy but not in preeclampsia
- Influence of urine volume on the assessment of intestinal permeability in affected children by multiple sugar probes
- Measurement of amino terminal propeptide of type III procollagen (PIIINP) employing the ADVIA Centaur platform. Validation, reference interval and comparison to UniQ RIA
- Cancer Diagnostics
- Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions
- Immunological screening for tumor cells in serous body fluids has added value with the CELL-DYN Sapphire
- Cardiovascular Diseases
- The value of clinical and laboratory diagnostics for chest pain patients at the emergency department
- The concentration of high-sensitivity troponin I, galectin-3 and NT-proBNP substantially increase after a 60-km ultramarathon
- Autoantibody prevalence with an improved immunoassay for detecting cardiac troponin-specific autoantibodies
- Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia
- Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women
- Infectious Diseases
- Analysis of antibody response (IgM, IgG, IgG3) to Chikungunya virus using panel of peptides derived from envelope protein for serodiagnosis
- Letters to the Editor
- A short story on how the H-index may change the fate of scientists and scientific publishing
- A new and effective way for preventing pre-analytical laboratory errors
- Digital immunofluorescence enables automated detection of antinuclear antibody endpoint titers avoiding serial dilution
- Multicenter method evaluation of the ARK™ Methotrexate Immunoassay
- Haemoglobinopathies in nonendemic areas in recent years
- Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: some results
- Effect of recalibration of the hs-TnT assay on diagnostic performance
