Abstract
Objectives
The aim of this paper is to introduce a new assist strategy for a direct assist device that can enhance the heart’s pumping efficiency and decrease the chances of myocardial injury in contrast to the conventional assist strategy.
Methods
We established a finite element model of a biventricular heart, divided the ventricles into several regions, and applied pressure to each region separately in order to identify the primary and secondary assist areas. Then combined and tested these areas to obtain the optimal assist strategy.
Results
The results indicate that our method exhibits an assist efficiency approximately ten times higher than that of the traditional assist method. Additionally, the stress distribution in the ventricles is more uniform after assistance.
Conclusions
In summary, this approach can result in a more homogenous stress distribution within the heart while also minimizing the contact area with it, which can reduce the incidence of allergic reactions and the likelihood of myocardial injury.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 51677082
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Research funding: Supported by the National Natural Science Foundation of China (51677082).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
References
1. Oeing, CU, Tschöpe, C, Pieske, B. The new ESC guidelines for acute and chronic heart failure 2016. Herz 2016;41:655–63. https://doi.org/10.1007/s00059-016-4496-3.Search in Google Scholar PubMed
2. Cox, G, Sleeper, L, Lowe, A, Towbin, JA, Colan, SD, Orav, EJ, et al.. Factors associated with establishing a causal diagnosis for children with cardiomyopathy. Pediatrics 2006;118:1519–31. https://doi.org/10.1542/peds.2006-0163.Search in Google Scholar PubMed
3. Lim, HS, Howell, N, Ranasinghe, A. The physiology of continuous-flow left ventricular assist devices. J Card Fail 2017;23:169–80. https://doi.org/10.1016/j.cardfail.2016.10.015.Search in Google Scholar PubMed
4. Cheever, EA, Thompson, DR, Smolik, BL, Santamore, W, George, D. Stimulator for skeletal muscle cardiac assist. IEEE Trans Biomed Eng 1998;45:56–67. https://doi.org/10.1109/10.650352.Search in Google Scholar PubMed
5. Tomoyuki, Y, Shigenao, M, Shintaro, A. Application of the shape memory alloy for the artificial internal organs. Available from: http://mec1.idac.tohoku. ac.jp/Welcome.files/cardiacmus.html.Search in Google Scholar
6. Yang, M, Mling, Z, Richardson, RC, Levesley, MC, Walker, PG, Watterson, K. Design and evaluation of linear ultrasonic motors for a cardiac compression assist device. Sens Actuators A Phys 2005;119:214–20. https://doi.org/10.1016/j.sna.2004.09.005.Search in Google Scholar
7. Ellen, TR, Markus, AH, Isaac, W, Alazmani, A, Song, SE, Whyte, W, et al.. Soft robotic sleeve supports heart function. Sci Transl Med 2017;9:1–11. https://doi.org/10.1126/scitranslmed.aaf3925.Search in Google Scholar PubMed
8. Gilbert, SH, Benson, AP, Li, P, Holden, AV. Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure. Eur J Cardio Thorac Surg Off J Eur Assoc Cardio Thorac Surg 2007;32:231–49. https://doi.org/10.1016/j.ejcts.2007.03.032.Search in Google Scholar PubMed
9. Wang, HM, Gao, H, Luo, XY, Berry, C, Griffith, BE, Ogden, RW, et al.. Structure-based finite strain modelling of the human left ventricle in diastole. Int J Num Methods Biomed Eng 2013;29:83–103. https://doi.org/10.1002/cnm.2497.Search in Google Scholar PubMed
10. Holzapfel, GA, Ogden, RW. Constitutive modelling of passive myocardium: a structurally based framework for material characterization. Philos Trans Royal Soc Math Phys Eng Sci 2009;367:3445–75. https://doi.org/10.1098/rsta.2009.0091.Search in Google Scholar PubMed
11. Sommer, G, Schriefl, AJ, Andrä, M, Sacherer, M, Viertler, C, Wolinski, H, et al.. Bio-mechanical properties and microstructure of human ventricular myocardium. Acta Biomater 2014;24:172–92. https://doi.org/10.1016/j.actbio.2015.06.031.Search in Google Scholar PubMed
12. He, M. Study on cardiac biomechanics using idealized and patient-specific models. University of Texas at Austin; 2014. Available from: http://hdl. handle. net/2152/28655.Search in Google Scholar
13. Zienkiewicz, OC, Taylor, RL. The finite element method for solid and structural mechanics, 6th ed. Oxford: Elsevier Butterworth-Heinemann; 2005.Search in Google Scholar
14. Sanchez-Ortiz, GI, Chandrashekara, R, Sermesant, M, Rhode, KS, Rueckert, D. Detecting the onset of myocardial contraction for establishing inverse electro-mechanical coupling in XMR guided RF ablation. In: Proceedings of IEEE international symposium on biomedical imaging. Arlington, USA: IEEE; 2004.Search in Google Scholar
15. Sermesant, M, Rhode, K, Sanchez-Ortiz, GI, Camara, O, Andriantsimiavona, R, Hegde, S, et al.. Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging. Med Image Anal 2005;9:467–80. https://doi.org/10.1016/j.media.2005.05.003.Search in Google Scholar PubMed
16. Thuy, P, Fatiesa, S, Erica, S, Wang, D, Sun, W. Quantification and comparison of the mechanical properties of four human cardiac valves. Acta Mater 2017;54:345–55. https://doi.org/10.1016/j.actbio.2017.03.026.Search in Google Scholar PubMed
17. Hurtado, DE, Kuhl, E. Computational modeling of electrocardiograms: repolarization and T‐wave polarity in the human heart. Comput Methods Biomech Biomed Eng 2014;17:986–96.10.1080/10255842.2012.729582Search in Google Scholar PubMed PubMed Central
18. Holzapfel, GA, Ogden, RW. Constitutive modelling of passive myocardium: a structurally based framework for material characterization. Philos Trans 2009;367:3445–75. https://doi.org/10.1098/rsta.2009.0091.Search in Google Scholar PubMed
19. Wenk, JF. Numerical modeling of stress in stenotic arteries with microcalcifications: a micromechanical approximation. J Biomech Eng 2010;132:091011. https://doi.org/10.1115/1.4001351.Search in Google Scholar PubMed
20. Peng, X, Guo, Z, Moran, B. An anisotropic hyperelastic constitutive model with fiber-matrix shear interaction for the human annulus fibrosus. J Appl Mech 2006;73:815–24. https://doi.org/10.1115/1.2069987.Search in Google Scholar
21. Zhang, C, Jianhang, W, Massoud, R, Wu, D, Hu, X. An integrative smoothed particle hydro-dynamics method for modeling cardiac function. Comput Methods Appl Mech Eng 2021;381:1–29.10.1016/j.cma.2021.113847Search in Google Scholar
22. Zhang, C, Jianhang, W, Massoud, R, Wu, D, Hu, X. An integrated SPH method for cardiac electromechanics. In: SPHERIC. US: New Jersey Institute of Technology, visual meeting; 2021.Search in Google Scholar
23. Tian, L. Modeling and simulation of hyper-elastic materials during cardiac motion [Master thesis]. Xi ’an University of Technology, MA: College of Mechanical and Electrical Engineering; 2019.Search in Google Scholar
24. Sotirios, K, William, DM, Mrudang, M, Sugerman, GP, Jazwiec, T, Malinowski, M, et al.. Right ventricular myocardial mechanics: multi-modal deformation, microstructure, modeling, and comparison to the left ventricle. Acta Biomater 2021;123:154–66. https://doi.org/10.1016/j.actbio.2020.12.006.Search in Google Scholar PubMed PubMed Central
25. Shimamoto, T, Sano, T, Ono, M. Analysis of cardiac function in its physiological & pathological conditions. Nihon Naika Gakkai Zasshi 1988;52:101–64.Search in Google Scholar
26. Wenk, JF, Papadopoulos, P, Zohdi, TI. Numerical modeling of stress in stenotic arteries with micro-calcifications: a micromechanical approximation. J Biomech Eng 2010;133:014503. https://doi.org/10.1115/1.4001351.Search in Google Scholar
27. Christopher, JP, Isaac, W, Colette, A, Thalhofer, T, Saeed, M, Bautista-Salinas, D, et al.. An implantable extracardiac soft robotic device for the failing heart: mechanical coupling and sync-hronization. Soft Robot 2017;4:241–50. https://doi.org/10.1089/soro.2016.0076.Search in Google Scholar PubMed
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Articles in the same Issue
- Frontmatter
- Review
- Research frontiers of electroporation-based applications in cancer treatment: a bibliometric analysis
- Research Articles
- Deep neural network to differentiate internet gaming disorder from healthy controls during stop-signal task: a multichannel near-infrared spectroscopy study
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- Effective deep learning classification for kidney stone using axial computed tomography (CT) images
- De- and recellularized urethral reconstruction with autologous buccal mucosal cells implanted in an ovine animal model
- The impact of right ventricular hemodynamics on the performance of a left ventricular assist device in a numerical simulation model
- Optimal assist strategy exploration for a direct assist device under stress‒strain dynamics
- Revisiting SFA stent technology: an updated overview on mechanical stent performance
- Parameter-based patient-specific restoration of physiological knee morphology for optimized implant design and matching
- Influences of smart glasses on postural control under single- and dual-task conditions for ergonomic risk assessment
Articles in the same Issue
- Frontmatter
- Review
- Research frontiers of electroporation-based applications in cancer treatment: a bibliometric analysis
- Research Articles
- Deep neural network to differentiate internet gaming disorder from healthy controls during stop-signal task: a multichannel near-infrared spectroscopy study
- A low power respiratory sound diagnosis processing unit based on LSTM for wearable health monitoring
- Effective deep learning classification for kidney stone using axial computed tomography (CT) images
- De- and recellularized urethral reconstruction with autologous buccal mucosal cells implanted in an ovine animal model
- The impact of right ventricular hemodynamics on the performance of a left ventricular assist device in a numerical simulation model
- Optimal assist strategy exploration for a direct assist device under stress‒strain dynamics
- Revisiting SFA stent technology: an updated overview on mechanical stent performance
- Parameter-based patient-specific restoration of physiological knee morphology for optimized implant design and matching
- Influences of smart glasses on postural control under single- and dual-task conditions for ergonomic risk assessment