Optical bone densitometry insensitive to skin thickness
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Kaname Miura
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Anak Khantachawana
Abstract
Skin thickness, including the adipose layer, which varies from individual to individual, affects the bone density measurement using light. In this study, we proposed a method to measure skin thickness using light and to correct the bias caused by differences in skin thickness and verified the proposed method by experiments using a phantom. We measured simulated skin of different thicknesses and bovine trabecular bone of different bone mineral densities (BMDs) using an optical system consisting of lasers of 850 and 515 nm wavelengths, lenses, and slits. Although the slope of the light intensity distribution formed on the surface of the material when irradiated by the 850 nm laser is affected by the thickness of the skin phantom. The difference of the intensity distribution peaks (δy) between the 850 and 515 nm lasers was strongly correlated with the thickness of the skin phantom. The coefficient of determination between the measurements and the BMD was improved by correcting the 850 nm laser measurements with δy. This result suggests that the method is applicable to optical bone densitometry, which is insensitive to differences in skin thickness.
Funding source: Kanazawa City
Award Identifier / Grant number: Creative Venture City Kanazawa Business Plan Award
Acknowledgments
The apparatus used in this study was made using the financial funding provided by Kanazawa City Japan.
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Research funding: This work was supported by Kanazawa City (Creative Venture City Kanazawa Business Plan Award).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors declare no financial or commercial conflict of interest.
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Code, data, and materials availability: The code, data, and materials that support the findings of this study are available from the corresponding author upon reasonable request.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Nano-material utilization in stem cells for regenerative medicine
- Active cell capturing for organ-on-a-chip systems: a review
- Research Articles
- Towards technically controlled bioreactor maturation of tissue-engineered heart valves
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- Effects of weight gaining to lower limb joint moments: a gender-specific sit-to-stand analysis
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Nano-material utilization in stem cells for regenerative medicine
- Active cell capturing for organ-on-a-chip systems: a review
- Research Articles
- Towards technically controlled bioreactor maturation of tissue-engineered heart valves
- In vitro thrombogenicity evaluation of rotary blood pumps by thromboelastometry
- Effects of weight gaining to lower limb joint moments: a gender-specific sit-to-stand analysis
- Evaluation method of ex vivo porcine liver reduced scattering coefficient during microwave ablation based on temperature
- Optical bone densitometry insensitive to skin thickness
- Computer aided detection of tuberculosis using two classifiers
