Evaluation method of ex vivo porcine liver reduced scattering coefficient during microwave ablation based on temperature

Xiaofei Jin; Wenwen Liu; Yiran Li; Lu Qian; Qiaoqiao Zhu; Weitao Li; Zhiyu Qian

doi:10.1515/bmt-2022-0189

Article

Evaluation method of ex vivo porcine liver reduced scattering coefficient during microwave ablation based on temperature

Xiaofei Jin , Wenwen Liu , Yiran Li , Lu Qian , Qiaoqiao Zhu , Weitao Li and Zhiyu Qian

Published/Copyright: September 12, 2022

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From the journal Biomedical Engineering / Biomedizinische Technik Volume 67 Issue 6

Abstract

The principle of microwave ablation (MWA) is to cause irreversible damage (protein coagulation, necrosis, etc.) to tumor cells at a certain temperature by heating, thereby destroying the tumor. We have long used functional near-infrared spectroscopy (fNIRs) to monitor clinical thermal ablation efficacy. After a lot of experimental verification, it can be found that there is a clear correlation between the reduced scattering coefficient and the degree of tissue damage. During the MWA process, the reduced scattering coefficient has a stable change. Therefore, both temperature (T) and reduced scattering coefficient ( μ s ′ ) are related to the thermal damage of the tissue. This paper mainly studies the changing law of T and μ s ′ during MWA and establishes a relationship model. The two-parameter simultaneous acquisition system was designed and used to obtain the T and μ s ′ of the ex vivo porcine liver during MWA. The correlation model between T and μ s ′ is established, enabling the quantitative estimation of μ s ′ of porcine liver based on T. The maximum and the minimum relative errors of μ s ′ are 79.01 and 0.39%, respectively. Through the electromagnetic simulation of the temperature field during MWA, 2D and 3D fields of reduced scattering coefficient can also be obtained using this correlation model. This study contributes to realize the preoperative simulation of the optical parameter field of microwave ablation and provide 2D/3D therapeutic effect for clinic.

Keywords: field; microwave ablation; reduced scattering coefficient; temperature

Corresponding author: Zhiyu Qian, Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China, E-mail: zhiyu@nuaa.edu.cn

Funding source: Jiangsu Province Key Research and Development Program (Social Development) Project

Award Identifier / Grant number: BE2020705

Funding source: National Major Scientific Instruments and Equipment Development Project Funded by National Natural Science Foundation of China

Award Identifier / Grant number: 81727804

Award Identifier / Grant number: 81827803

Funding source: Jiangsu Province University Student Innovation and Entrepreneurship Training Program

Award Identifier / Grant number: 202010287208T

Funding source: Natural Science Foundation of Jiangsu Province

Award Identifier / Grant number: BK20190387

Funding source: National Natural Science Foundation of China

Award Identifier / Grant number: 11902154

Award Identifier / Grant number: 61875085

Acknowledgments

This study was supported by National Major Scientific Instruments and Equipment Development Project Funded by National Natural Science Foundation of China (81827803, 81727804), National Natural Science Foundation of China (61875085, 11902154), Jiangsu Province Key Research and Development Program (Social Development) Project (BE2020705), Natural Science Foundation of Jiangsu Province (BK20190387), National Major Project Cultivation Fund of Nanjing University of Aeronautics and Astronautics (NP2020303), and Jiangsu Province University Student Innovation and Entrepreneurship Training Program (202010287208T).

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: All animals were kept in a pathogen-free environment and fed ad lib. The study protocol was approved by the ethics review board of the Hunan Cancer Hospital. All of the procedures were performed in accordance with the Declaration of Helsinki and relevant policies in China.
Disclosure statement: The authors declare that they have no conflict of interest.

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Received: 2022-05-08

Accepted: 2022-08-01

Published Online: 2022-09-12

Published in Print: 2022-12-16

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Articles in the same Issue

https://doi.org/10.1515/bmt-2022-0189

Keywords for this article

field; microwave ablation; reduced scattering coefficient; temperature