Evaluation of a new non-invasive measurement technique based on bioimpedance spectroscopy to estimate blood alcohol content: a pilot study
-
Michael Czaplik
,
Mark Ulbrich
Abstract
The gold standard for estimating blood alcohol content (BAC) after alcohol consumption is a blood sample analysis. An innovative technology to estimate BAC is based on impedance cardiography and bioimpedance spectroscopy (BIS). This study investigated whether it is possible to estimate increasing blood alcohol levels during a drinking trial with bioimpedance measurement techniques. Twenty-one healthy volunteers were assigned to a test (ethanol) group (ETH) or a reference group (H2O). After baseline measurements, the ETH group ingested 120 ml of vodka, followed by a resorption phase of 50 min. Then, bioimpedance and breath alcohol measurements were performed. Thereafter, 60 ml of vodka was ingested and another resorption phase of 50 min was followed by bioimpedance and breath alcohol measurements. This procedure was repeated until alcohol levels exceeded 0.4 mg/l. The H2O group performed in the same way with water. For all measurements, extracellular resistance (Re) and the base impedance (Z0) were computed. Regarding BIS, several parameters differed significantly between the ETH and the H2O group. Re increased in ETH (p=0.005), but not in the H2O group when comparing the first and last measurements. Z0 also increased significantly in the ETH group (p=0.001). To conclude, with BIS measurements, it is possible to measure increasing blood alcohol levels.
Acknowledgments
Special thanks go to Angela Sudhoff and Verena Deserno from the Clinical Trial Center in Aachen (CTC-A) and the Center for Laboratory Diagnostics at the University Hospital Aachen.
Author Statement
Research funding: Michael Czaplik was funded by the Medical Faculty at RWTH Aachen University.
Conflict of interest: Authors state no conflict of interest.
Informed consent: All participants signed an informed consent form.
Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance to the tenets of the Declaration of Helsinki and has been approved by the local ethics committee (EK 062/12).
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Artikel in diesem Heft
- Frontmatter
- Review
- Current state of total artificial heart therapy and introduction of the most important total artificial heart systems
- Research articles
- Impact of strut dimensions and vessel caliber on thrombosis risk of bioresorbable scaffolds using hemodynamic metrics
- A coefficient-free and continuous blood pressure estimation method based on the arterial lumen area model
- High-frequency wall vibrations in a cerebral patient-specific aneurysm model
- Study of a retinal layer model to generate a spike waveform for a color deficient and strabismus individual
- Retinal images benchmark for the detection of diabetic retinopathy and clinically significant macular edema (CSME)
- Robust EOG-based saccade recognition using multi-channel blind source deconvolution
- Investigation of the mirrored-word reading paradigm for BCI implementation
- Biomechanical analysis of spinal implants with different rod diameters under static and fatigue loads: an experimental study
- Setup and initial testing of an endoscope manipulator system for assistance in transoral endoscopic surgery
- A theoretical study of digital silicon photomultiplier utilization in diffuse optical imaging systems
- Evaluation of a new non-invasive measurement technique based on bioimpedance spectroscopy to estimate blood alcohol content: a pilot study
