Abstract
Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.
Author Statement
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent is not applicable.
Ethical approval: The conducted research is not related to either human or animals use.
References
[1] Binzoni T, Leung TS, Van De Ville D. The photo-electric current in laser-Doppler flowmetry by Monte Carlo simulations. Phys Med Biol 2009; 54: N303–N318.10.1088/0031-9155/54/14/N03Search in Google Scholar PubMed
[2] Bonner RF, Nossal R. Model for laser Doppler measurements of blood flow in tissue. Appl Opt 1981; 20: 2097–2107.10.1364/AO.20.002097Search in Google Scholar PubMed
[3] Department of Biomedical Engineering, Linköping University (SWE). Laser doppler flowmetry – a theoretical framework. Linköping, 2007.Search in Google Scholar
[4] Lapitan DG, Rogatkin DA. Improved two-channel laser Doppler flowmeter//IEEE Xplore: Proceedings of 2016 International Conference Laser Optics, LO 2016, 7549973: S2–S16.10.1109/LO.2016.7549973Search in Google Scholar
[5] Nilsson GE, Tenland T, Oberg PA. A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy. IEEE Trans Biomed Eng 1980; 27: 12–19.10.1109/TBME.1980.326686Search in Google Scholar PubMed
[6] Nilsson GE, Tenland T, Oberg PA. Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng 1980; 27: 597–604.10.1109/TBME.1980.326582Search in Google Scholar PubMed
[7] Nilsson GE, Tenland T, Oberg PA. Method and apparatus for measuring flow motions in a fluid. U.S. Patent No. 4,476,875. 16 Oct. 1984.Search in Google Scholar
[8] Rajan V, Varghese B, Leeuwen TG, Steenbergen W. Review of methodological developments in laser Doppler flowmetry. Lasers Med Sci 2009; 24: 269–283.10.1007/s10103-007-0524-0Search in Google Scholar PubMed
[9] Rogatkin D, Shumskiy V, Tereshenko S, Polyakov P. Laser-based non-invasive spectrophotometry – an overview of possible medical application. Photonics Lasers Med 2013; 2: 225–240.10.1515/plm-2013-0010Search in Google Scholar
[10] Roustit M, Cracowski JL. Non-invasive assessment of skin microvascular function in humans: an insight into methods. Microcirculation 2012; 19: 47–64.10.1111/j.1549-8719.2011.00129.xSearch in Google Scholar PubMed
[11] Tew GA, Klonizakis M, Moss J, Ruddock AD, Saxton JM, Hodges GJ. Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvasc Res 2011; 81: 177–182.10.1016/j.mvr.2010.12.001Search in Google Scholar PubMed
[12] Wojtkiewicz S, Liebert A, Rix H, Maniewski R. Evaluation of algorithms for microperfusion assessment by fast simulations of laser Doppler power spectral density. Phys Med Biol 2011; 56: 7709–7723.10.1088/0031-9155/56/24/002Search in Google Scholar PubMed
©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- In-service characterization of a polymer wick-based quasi-dry electrode for rapid pasteless electroencephalography
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- Fused multivariate empirical mode decomposition (MEMD) and inverse solution method for EEG source localization
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Articles in the same Issue
- Frontmatter
- Research articles
- A new in vitro spine test rig to track multiple vertebral motions under physiological conditions
- In-service characterization of a polymer wick-based quasi-dry electrode for rapid pasteless electroencephalography
- Spike detection using a multiresolution entropy based method
- Obstacles in using a computer screen for steady-state visually evoked potential stimulation
- Classification of pulmonary pathology from breath sounds using the wavelet packet transform and an extreme learning machine
- Filtering of ECG signals distorted by magnetic field gradients during MRI using non-linear filters and higher-order statistics
- Failure analysis of eleven Gates Glidden drills that fractured intraorally during post space preparation. A retrieval analysis study
- Assessing multiple muscle activation during squat movements with different loading conditions – an EMG study
- In-vivo monitoring of infection via implantable microsensors: a pilot study
- Analysis of structural brain MRI and multi-parameter classification for Alzheimer’s disease
- False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter
- A priori knowledge integration for the detection of cerebral aneurysm
- Is the location of the signal intensity weighted centroid a reliable measurement of fluid displacement within the disc?
- Image-based 3D surface approximation of the bladder using structure-from-motion for enhanced cystoscopy based on phantom data
- Fused multivariate empirical mode decomposition (MEMD) and inverse solution method for EEG source localization
- Quantifying the dynamics of electroencephalographic (EEG) signals to distinguish alcoholic and non-alcoholic subjects using an MSE based K-d tree algorithm
- A hybrid active force control of a lower limb exoskeleton for gait rehabilitation
- Short communication
- Can somatosensory electrical stimulation relieve spasticity in post-stroke patients? A TMS pilot study