Abstract
Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signal-intensity-weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weighted-centroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements. Discs were semi-automatically segmented into a whole disc, nucleus, anterior and posterior annulus. The coordinates of the signal-intensity-weighted-centroid for all regions demonstrated excellent intraclass-correlation-coefficients for intra- (0.99–1.00) and inter-rater reliability (0.97–1.00). The standard error of measurement for the Y-coordinates of the signal-intensity-weighted-centroid for all ROIs were 0 at both levels and 0 to 2.7 mm for X-coordinates. The mean signal intensity and area for the whole disc and nucleus presented excellent intra-rater reliability with intraclass-correlation-coefficients from 0.93 to 1.00, and 0.92 to 1.00 for inter-rater reliability. The mean signal intensity and area had lower reliability for annulus ROIs, with intra-rater intraclass-correlation-coefficient from 0.5 to 0.76 and inter-rater from 0.33 to 0.58. The location of the signal-intensity-weighted-centroid is a reliable biomarker for investigating the effects of disc interventions.
Author Statement
Research funding: Vahid Abdollah was a recipient of the University of Alberta Doctoral Recruitment Scholarship. All authors were recipients of a research grant provided by the Alberta Spine Foundation for the development of a program for automatic quantitative measurements of lumbar disc and vertebra signal intensity and morphology using T2-weighted MR images. Data collection was as part of a study entitled: Creating a Prediction Rule to Identify Patients Likely to Respond to Extension-Oriented Exercises and Understanding the Mechanisms in Persons with LBP: A Study Using Clinical, MRI and Neuromuscular Assessment. conducted by J. Fritz (PI), A. Cottrell, B. Hayes, E. Parent, K. Sanders funded by a collaborative grant from the Center for Contemporary Rehabilitation Research, Education and Practice (A collaborative Between Rehabilitation Services, PM&R and College of Health) from December 2006 to 2007.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent has been obtained from all individuals.
Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies, was performed in accordance with the tenets of the Helsinki Declaration, and has been approved by University of Alberta's Health Research Ethics Review Board.
References
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Research articles
- A new in vitro spine test rig to track multiple vertebral motions under physiological conditions
- In-service characterization of a polymer wick-based quasi-dry electrode for rapid pasteless electroencephalography
- Spike detection using a multiresolution entropy based method
- Obstacles in using a computer screen for steady-state visually evoked potential stimulation
- Classification of pulmonary pathology from breath sounds using the wavelet packet transform and an extreme learning machine
- Filtering of ECG signals distorted by magnetic field gradients during MRI using non-linear filters and higher-order statistics
- Failure analysis of eleven Gates Glidden drills that fractured intraorally during post space preparation. A retrieval analysis study
- Assessing multiple muscle activation during squat movements with different loading conditions – an EMG study
- In-vivo monitoring of infection via implantable microsensors: a pilot study
- Analysis of structural brain MRI and multi-parameter classification for Alzheimer’s disease
- False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter
- A priori knowledge integration for the detection of cerebral aneurysm
- Is the location of the signal intensity weighted centroid a reliable measurement of fluid displacement within the disc?
- Image-based 3D surface approximation of the bladder using structure-from-motion for enhanced cystoscopy based on phantom data
- Fused multivariate empirical mode decomposition (MEMD) and inverse solution method for EEG source localization
- Quantifying the dynamics of electroencephalographic (EEG) signals to distinguish alcoholic and non-alcoholic subjects using an MSE based K-d tree algorithm
- A hybrid active force control of a lower limb exoskeleton for gait rehabilitation
- Short communication
- Can somatosensory electrical stimulation relieve spasticity in post-stroke patients? A TMS pilot study
Articles in the same Issue
- Frontmatter
- Research articles
- A new in vitro spine test rig to track multiple vertebral motions under physiological conditions
- In-service characterization of a polymer wick-based quasi-dry electrode for rapid pasteless electroencephalography
- Spike detection using a multiresolution entropy based method
- Obstacles in using a computer screen for steady-state visually evoked potential stimulation
- Classification of pulmonary pathology from breath sounds using the wavelet packet transform and an extreme learning machine
- Filtering of ECG signals distorted by magnetic field gradients during MRI using non-linear filters and higher-order statistics
- Failure analysis of eleven Gates Glidden drills that fractured intraorally during post space preparation. A retrieval analysis study
- Assessing multiple muscle activation during squat movements with different loading conditions – an EMG study
- In-vivo monitoring of infection via implantable microsensors: a pilot study
- Analysis of structural brain MRI and multi-parameter classification for Alzheimer’s disease
- False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter
- A priori knowledge integration for the detection of cerebral aneurysm
- Is the location of the signal intensity weighted centroid a reliable measurement of fluid displacement within the disc?
- Image-based 3D surface approximation of the bladder using structure-from-motion for enhanced cystoscopy based on phantom data
- Fused multivariate empirical mode decomposition (MEMD) and inverse solution method for EEG source localization
- Quantifying the dynamics of electroencephalographic (EEG) signals to distinguish alcoholic and non-alcoholic subjects using an MSE based K-d tree algorithm
- A hybrid active force control of a lower limb exoskeleton for gait rehabilitation
- Short communication
- Can somatosensory electrical stimulation relieve spasticity in post-stroke patients? A TMS pilot study