Abstract
Gelatin (Gel) has been reported as a promising candidate in tissue engineering owing to its easy availability, biocompatibility, and biodegradability. Gel hydrogel is of potential to be cross-linked with different materials to enhance their biocompatibility for cell culture for tissue engineering applications. The mechanical properties of this versatile material, however, have not been thoroughly determined. In this study, the linear elastic (Young’s modulus and maximum stress) and non-linear hyperelastic (hyperelastic coefficients) mechanical properties of prepared hydrogels at different contents of Gel (wt%) were measured, and its Young’s modulus was compared with that of skin tissue. The prepared cylindrical Gel hydrogels were subjected to a series of unconfined compression tests. The hyperelastic strain energy density function was calibrated using the compressive experimental data. The potential ability of the Yeoh hyperelastic constitutive equation, which has been proposed as the best material model to represent the non-linear behavior of hydrogels, was verified using finite element (FE) simulations. The results revealed that the Young’s modulus and maximum stress of hydrogels are increased by the addition of Gel. The highest Young’s modulus (81 kPa) and maximum stress (24 kPa) were observed for hydrogels with 15 wt% Gel. Results also showed that the hydrogels with a relatively lower content (<7.5 wt%) of Gel have suitable Young’s modulus compared with those with a higher content (>7.5 wt%) for skin tissue engineering. The Yeoh material model was closely fitted with the experimental data and could be used in further biomechanical simulations of the hydrogels. The experimental results were also compared well with those predicted by the FE models. The results of this study might have implications not only for the understanding of the mechanical properties of Gel hydrogel but also for the fabrication of polymeric substrate materials suitable for skin tissue engineering applications.
Acknowledgments
The authors acknowledge the Iran University of Science and Technology (Mechanical Engineering Department) for funding this project.
Conflicts of interest statement:
The authors declare that they have no conflicts of interest.
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©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Research articles
- Analysis of emboli and blood flow in the ophthalmic artery to understand retinal artery occlusion
- Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications
- Red light as a 12-oxo-leukotriene B4 antagonist: an explanation for the efficacy of intensive red light in the therapy of peripheral inflammatory diseases
- Tightening of healing abutments: influence of torque on bacterial proliferation risk, an in vitro investigation
- Influence of superstructure geometry on the mechanical behavior of zirconia implant abutments: a finite element analysis
- Biomechanical investigations of the secondary stability of commercial short dental implants in porcine ribs
- Automatic camera-based identification and 3-D reconstruction of electrode positions in electrocardiographic imaging
- An automatic saccadic eye movement detection in an optokinetic nystagmus signal
- Case Report
- Monitoring of lobectomy in cystic fibrosis with electrical impedance tomography – a new diagnostic tool
- Letters to the Editor
- Accelerometer-based goniometer for smartphone and manual measurement on photographs: do they agree?
- Reply to: Accelerometer-based goniometer for smartphone and manual measurement on photographs: do they agree?
Artikel in diesem Heft
- Frontmatter
- Research articles
- Analysis of emboli and blood flow in the ophthalmic artery to understand retinal artery occlusion
- Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications
- Red light as a 12-oxo-leukotriene B4 antagonist: an explanation for the efficacy of intensive red light in the therapy of peripheral inflammatory diseases
- Tightening of healing abutments: influence of torque on bacterial proliferation risk, an in vitro investigation
- Influence of superstructure geometry on the mechanical behavior of zirconia implant abutments: a finite element analysis
- Biomechanical investigations of the secondary stability of commercial short dental implants in porcine ribs
- Automatic camera-based identification and 3-D reconstruction of electrode positions in electrocardiographic imaging
- An automatic saccadic eye movement detection in an optokinetic nystagmus signal
- Case Report
- Monitoring of lobectomy in cystic fibrosis with electrical impedance tomography – a new diagnostic tool
- Letters to the Editor
- Accelerometer-based goniometer for smartphone and manual measurement on photographs: do they agree?
- Reply to: Accelerometer-based goniometer for smartphone and manual measurement on photographs: do they agree?