Startseite In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model
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In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model

  • Tobias Schilling EMAIL logo , Gudrun Brandes , Igor Tudorache , Serghei Cebotari , Andres Hilfiker , Tanja Meyer , Christian Biskup , Michael Bauer , Karl-Heinz Waldmann , Friedrich-Wilhelm Bach , Axel Haverich und Thomas Hassel
Veröffentlicht/Copyright: 29. August 2013
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Abstract

Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host’s cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs’ organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.


Corresponding author: Tobias Schilling, MD, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, Phone: +49-511-532-6584, Fax: +49-511-532-5404, E-mail:

The project is funded by the German Research Foundation (Collaborative Research Center (SFB) 599/ Project R7). The excellent technical assistance of Christian Klose (Institute of Material Science, Leibniz University Hannover, Hannover, Germany) and Elke Mallon (Institute of Cell Biology in the Center of Anatomy, Medical School Hannover, Hannover, Germany) is highly appreciated. We are very grateful to Dr. Petra Wolf (Institute for Animal Nutrition, University of Veterinary Medicine, Foundation, Hannover, Germany) for analyzing the concentration of magnesium ions in the explanted tissues.

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Received: 2013-5-30
Accepted: 2013-7-19
Published Online: 2013-08-29
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

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