Highlight: The Biology of Proteolytic Systems

Artikel in diesem Heft

1. Guest Editorial
2. Highlight: The Biology of Proteolytic Systems
3. Highlight: 6th General Meeting of the International Proteolysis Society
4. Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases
5. Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions
6. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease
7. Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining
8. Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer
9. Proteolysis of platelet receptors in humans and other species
10. Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites
11. Impaired turnover of autophagolysosomes in cathepsin L deficiency
12. Nuclear cysteine cathepsin variants in thyroid carcinoma cells
13. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer
14. Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis
15. Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8)
16. Molecular contortionism – on the physical limits of serpin ‘loop-sheet’ polymers
17. The substrate specificity profile of human granzyme A
18. Use of granzyme B-based fluorescent protein reporters to monitor granzyme distribution and granule integrity in live cells