Combination antiretroviral therapy with protease inhibitors in HIV-infected pregnancy
-
Chi P. Dola
,
Rubina Khan
Abstract
Objective: To evaluate the possible association between protease inhibitor (PI) and premature birth and low birth-weight in HIV-infected pregnancies.
Materials and methods: Data were collected retrospectively for maternal and pregnancy characteristics, antiretroviral medication, lowest CD4 count and highest viral load during pregnancy, and pregnancy outcomes. χ2 Analysis, Student’s t-test, and multiple logistic regression analysis were performed.
Results: Data from 161 HIV-infected women who delivered singleton gestation were analyzed. Fifty-three received an antepartum regimen with PI, 84 received a regimen without PI, and six did not receive antepartum treatment. The mean estimated gestational age (EGA)±SD at delivery was 37.7±3.2 weeks. The premature birth rate was 18.4%. No difference was detected between women receiving the antiretroviral regimen including PI and those on the regimen without PI or on no antepartum medication with regard to: EGA±SD at delivery (37.7±3.2 vs. 37.6±3.1 weeks, respectively, P=0.87), rate of premature birth (14% vs. 20.6%, respectively, P=0.32) and low birth-weight (12.5% vs. 20.2%, respectively, P=0.25). In multiple logistic regression analysis, PI was not associated with premature birth or low birth-weight.
Conclusion: Women receiving antiretroviral therapy with PI have a similar rate of premature birth and low birth-weight as women receiving antiretroviral therapy without PI or on no medication.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Review article
- WAPM Working Group on Nutrition: Potential chronobiotic role of human milk in sleep regulation
- Opinion Paper
- “Every case of asphyxia can be used as a learning example”. Conclusions from an analysis of substandard obstetrical care
- Original Articles – Obstetrics
- Hematologic profile of the fetus with systemic inflammatory response syndrome
- Optimized amniotic fluid analysis in patients suspected of intrauterine infection/inflammation
- Risk factors for preterm delivery with placenta previa
- Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study
- Combination antiretroviral therapy with protease inhibitors in HIV-infected pregnancy
- Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women
- The impact of the time interval between two successive deliveries in an obstetric unit in terms of the mode of each delivery and the rate of perinatal mortality
- Original Articles – Fetus
- Terbutaline: effects on the fetal heart at term
- Parallel maternal and fetal immune activation by bacterial toxins in vitro
- Original Articles – Newborn
- Prepregnancy body mass index, socioeconomic status, race/ethnicity and breastfeeding practices
- Fetal and neonatal outcome in patients with anterior abdominal wall defects (gastroschisis and omphalocele)
- Total serum bilirubin level in umbilical cord blood and respiratory distress syndrome in very low birth weight infants
- Short Communication
- Improved overall delivery documentation following implementation of a standardized shoulder dystocia delivery form
- Letters to the Editor
- Prevention of prematurity – a complex undertaking
- Prevention of prematurity – a complex undertaking reply
- Congress calendar
- 10.1515/JPM-2011-1000
