Optimized amniotic fluid analysis in patients suspected of intrauterine infection/inflammation
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Catherine Ford
Abstract
Objective: To determine the combination of amniotic fluid (AF) tests with the best diagnostic accuracy for predicting intrauterine infection/inflammation (IUI) in patients with clinical suspicion of chorioamnionitis.
Study design: This is a retrospective study of 34 pregnant women who presented with uterine tenderness, maternal fever, maternal tachycardia, and/or fetal tachycardia and underwent AF analysis. IUI diagnosis was based on placental histology, positive AF bacterial cultures, and/or Gram stain.
Result: Logistic regression analysis revealed a significant relationship between IUI and AF glucose. Glucose is more sensitive than culture or Gram stain (64% vs. 40% and 20%, [iw-0.3]respectively). Culture and glucose combined achieved the best diagnostic accuracy (sensitivity, 71%; specificity, 100%; positive and negative predictive values, 100–83%, respectively).
Conclusion: Positive AF Gram stain or glucose <15 mg/dL strongly suggests IUI in symptomatic patients. If both tests are negative, the result of culture should aid the management.
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Review article
- WAPM Working Group on Nutrition: Potential chronobiotic role of human milk in sleep regulation
- Opinion Paper
- “Every case of asphyxia can be used as a learning example”. Conclusions from an analysis of substandard obstetrical care
- Original Articles – Obstetrics
- Hematologic profile of the fetus with systemic inflammatory response syndrome
- Optimized amniotic fluid analysis in patients suspected of intrauterine infection/inflammation
- Risk factors for preterm delivery with placenta previa
- Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study
- Combination antiretroviral therapy with protease inhibitors in HIV-infected pregnancy
- Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women
- The impact of the time interval between two successive deliveries in an obstetric unit in terms of the mode of each delivery and the rate of perinatal mortality
- Original Articles – Fetus
- Terbutaline: effects on the fetal heart at term
- Parallel maternal and fetal immune activation by bacterial toxins in vitro
- Original Articles – Newborn
- Prepregnancy body mass index, socioeconomic status, race/ethnicity and breastfeeding practices
- Fetal and neonatal outcome in patients with anterior abdominal wall defects (gastroschisis and omphalocele)
- Total serum bilirubin level in umbilical cord blood and respiratory distress syndrome in very low birth weight infants
- Short Communication
- Improved overall delivery documentation following implementation of a standardized shoulder dystocia delivery form
- Letters to the Editor
- Prevention of prematurity – a complex undertaking
- Prevention of prematurity – a complex undertaking reply
- Congress calendar
- 10.1515/JPM-2011-1000
