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Effect of exogenous surfactant therapy on levels of pulmonary surfactant proteins A and D in preterm infants with respiratory distress syndrome

  • Young Min Bae , Chong-Woo Bae , Myung Ho Oh , Sang Han Lee , Kee Min Woo and Keum Bun Jung
Published/Copyright: June 3, 2009
Journal of Perinatal Medicine
From the journal Volume 37 Issue 5

Abstract

Objectives: To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely supplement endogenous pulmonary surfactants (enPS) by looking at sequential changes in the surfactant proteins (SP) SP-A and SP-D in alveolar pools.

Methods: Fourteen preterm infants with RDS treated with an artificial surfactant were compared to five normal-term infants without RDS who were treated with artificial ventilation at birth.

Results: Immediately after birth, SP-A and SP-D were essentially absent in the alveolar pools of the RDS group, but were present at normal levels in the controls. Treatment with exPS apparently stimulated enPS production.

Conclusions: In infants who responded well to exPS therapy, the SP concentration reached essentially normal levels within 48–72 h after birth.

Keywords: Endogenous pulmonary surfactants; exogenous pulmonary surfactants; surfactant proteins
Corresponding author: Chong-Woo Bae, MD, PhD Department of Pediatrics College of Medicine Kyunghee University East-West Neo Medical Center 149 Sangil-dong Kangdong-ku Seoul 134-727 Korea Tel.: +82-2-440-6130 Fax: +82-2-440-7175
Received: 2008-12-11
Revised: 2009-3-19
Accepted: 2009-4-3
Published Online: 2009-06-03
Published Online: 2009-06-03
Published in Print: 2009-09-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/JPM.2009.100
Keywords for this article
Endogenous pulmonary surfactants; exogenous pulmonary surfactants; surfactant proteins

Articles in the same Issue

  1. Recommendations and guidelines for perinatal practice
  2. Guidelines on CMV congenital infection
  3. Minireviews
  4. Towards new diagnostic criteria for diagnosing GDM – the HAPO study
  5. Surveillance during labour
  6. Limit of viability in Japan: ethical consideration
  7. Review article
  8. Outpatient induction – how safe
  9. Original articles – Obstetrics
  10. Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus
  11. A randomized trial of cerclage vs. 17 α-hydroxyprogesterone caproate for treatment of short cervix
  12. Umbilical cord insertion site in early gestation and development of placenta
  13. Inappropriate use of vancomycin for preventing perinatal group B streptococcal (GBS) disease in laboring patients
  14. Vitamin D receptor genotype BB is associated with higher serum osteocalcin in first pregnancy
  15. Arylsulphatase A activity and sulphatide concentration in placenta, membranes and cord after delivery
  16. Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation
  17. Long chain polyunsaturated fatty acids in mothers and term babies
  18. Body mass index, Bishop score, and sonographic measurement of the cervical length as predictors of successful labor induction in twin gestations
  19. Original articles – Fetus
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  21. Fetal short time variation during labor: a non-invasive alternative to fetal scalp pH measurements?
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  30. Elective cesarean delivery at 38 weeks' gestation: Is the timing too early?
  31. Grasping activity in utero: a significant indicator of fetal behavior (The role of the grasping reflex in fetal ethology)
  32. Reply
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  34. Obituary
  35. The death of Prof. Albert Huch
  36. Congress calendar
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  38. Erratum
  39. Hematological profile of Korean very low birth weight infants
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