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Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus
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Marco Scioscia
Published/Copyright:
June 3, 2009
Abstract
A progressive insulin resistant state develops throughout human pregnancy. Inositol phosphoglycan P-type (P-IPG), a second messenger of insulin, was reported to negatively correlate with the degree of insulin resistance in non-pregnant diabetic subjects. Urinary levels of P-IPG were assessed in insulin resistant states during pregnancy such as gestational diabetes mellitus (GDM, n=44) and type 2 diabetes mellitus (type 2 DM, n=25) and in 69 normal pregnant women. Urinary levels of P-IPG were higher in GDM than controls with a positive trend of release throughout normal pregnancy (P<0.01). P-IPG excretion was higher in diabetic (GDM and type 2 DM) than in healthy women in the second trimester (P<0.05). A higher P-IPG urinary excretion occurs during the second trimester in pregnant women with clinically evident insulin resistance with a positive association with poor glycemic control.
Keywords: Diabetes type 2; gestational diabetes mellitus; glycemic control; inositol phosphoglycan; pregnancy
Received: 2008-12-30
Accepted: 2009-3-19
Published Online: 2009-06-03
Published Online: 2009-06-03
Published in Print: 2009-09-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
Diabetes type 2;
gestational diabetes mellitus;
glycemic control;
inositol phosphoglycan;
pregnancy
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