Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
-
Lei Shi
Abstract
Aim: Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of premature infants. The role of cytokines and growth factors in the pathophysiology of NEC is not yet clearly defined. Among these factors, the intestinal trefoil factor (ITF) is known as cytoprotective to the gut. We studied the cytoprotective effect of trefoil factor in the 1-day-old Wistar rat pup model following hypoxic-ischemic cold stress.
Materials and methods: In the present study, thirty 1-day-old Wistar rat pups were randomly divided into three groups: Group 1, normal controls: Group 2, NEC; Group 3, NEC+ITF. Experimental NEC was induced by exposure to hypoxia for 60 s followed by cold stress at 4°C for 10 min. The animals were euthanized at development of NEC, and at 96 h the intestinal tissue was processed and examined for histological changes of NEC.
Results: The pathological lesions indicated severe separation of the submucosa and lamina propria and tissue necrosis in Group 2, and slight submucosal and lamina propria separation in Group 3. There were no histopathological changes in the controls. The mean of histological grade of group 2 was 2.8 (range 2–4), and 1.2 (range 0–2) in group 3. A difference was found when the two groups were compared (P<0.05).
Conclusion: ITF may provide a new way for the therapy of NEC in rats.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?
- Clinical-radiological features of fractures in premature infants – a review
- Scientific and religious controversies about the beginning of human life: the relevance of the ethical concept of the fetus as a patient
- The status of the embryo in Buddhism: opinions on scientific and religious controversies about the beginning of human life
- The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes
- Validity of amniotic fluid index in preterm rupture of membranes
- Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations
- Ductus venosus Doppler measurement during labor
- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to cardiotocography to predict fetal acidosis in labor / A multi-center, case controlled study
- Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses
- MRI and multiplanar 3D ultrasound compared in the prenatal assessment of enlarged posterior fossa
- Monochorionic twins in which at least one fetus has a congenital heart disease with or without twin-twin transfusion syndrome
- Enriched post-discharge formula versus term formula for bone strength in very low birth weight infants: a longitudinal pilot study
- Which information will be given to parents of preterm infants – a comparison of estimates and local data
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Impact of being small-for-gestational age on survival and long-term outcome of extremely premature infants born at 23–27 weeks' gestation
- Gastroschisis: brief early history
- Reply
- Congress Calendar
Articles in the same Issue
- Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?
- Clinical-radiological features of fractures in premature infants – a review
- Scientific and religious controversies about the beginning of human life: the relevance of the ethical concept of the fetus as a patient
- The status of the embryo in Buddhism: opinions on scientific and religious controversies about the beginning of human life
- The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes
- Validity of amniotic fluid index in preterm rupture of membranes
- Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations
- Ductus venosus Doppler measurement during labor
- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to cardiotocography to predict fetal acidosis in labor / A multi-center, case controlled study
- Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses
- MRI and multiplanar 3D ultrasound compared in the prenatal assessment of enlarged posterior fossa
- Monochorionic twins in which at least one fetus has a congenital heart disease with or without twin-twin transfusion syndrome
- Enriched post-discharge formula versus term formula for bone strength in very low birth weight infants: a longitudinal pilot study
- Which information will be given to parents of preterm infants – a comparison of estimates and local data
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Impact of being small-for-gestational age on survival and long-term outcome of extremely premature infants born at 23–27 weeks' gestation
- Gastroschisis: brief early history
- Reply
- Congress Calendar
