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Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations
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Yaprak Engin-Üstün
Published/Copyright:
August 9, 2007
Abstract
Objective: To establish the adenosine deaminase (ADA) activity in women who had been pregnant with a child suffering from central nervous system (CNS) anomaly.
Methods: The study group comprised 68 women who had been pregnant with an affected child, and 68 controls matched for age, gestational age and body mass index. Maternal venous blood was collected for measurement of ADA levels. We defined the diagnostic sensitivity, specificity and area under receiver-operating characteristic curve for ADA.
Results: Plasma ADA activity was significantly higher in the study group (12.3 U/L, range 1.7–33.3) compared to the median value of 3.3 U/L (range 1.1–34.4) in normal pregnancies (P<0.05). The cut-off point of ADA >5.9U/L was associated with the highest combination of specificity (58.8%) and sensitivity (86.8%).
Conclusion: ADA activity in women who have conceived a fetus with CNS malformations was significantly higher than that in normal pregnant women.
Keywords: Adenosine deaminase; CNS malformations
Received: 2006-12-9
Revised: 2007-4-9
Accepted: 2007-5-15
Published Online: 2007-08-09
Published in Print: 2007-10-01
©2007 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?
- Clinical-radiological features of fractures in premature infants – a review
- Scientific and religious controversies about the beginning of human life: the relevance of the ethical concept of the fetus as a patient
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- The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes
- Validity of amniotic fluid index in preterm rupture of membranes
- Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations
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- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to cardiotocography to predict fetal acidosis in labor / A multi-center, case controlled study
- Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses
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