Enriched post-discharge formula versus term formula for bone strength in very low birth weight infants: a longitudinal pilot study
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Ita Litmanovitz
Abstract
Aim: To initiate a longitudinal pilot study comparing the effect of nutrient-enriched post-discharge formula (PDF) with standard term formula (TF) on bone strength of very low birth weight (VLBW) infants in the first six months post-term.
Methods: Two matched groups of VLBW infants were randomly assigned to enriched PDF (n=10) or TF (n=10) at corrected age of 40 weeks. Anthropometric measurements of growth and measurements of bone speed of sound (SOS) indicating bone strength and bone turnover markers (bone-specific alkaline phosphatase and cross-linked carboxy terminal telopeptide of type I collagen) were taken at term and at three and six months corrected age.
Results: The anthropometric measurements of infants fed PDF and TF were comparable at three and six months corrected age. Bone SOS of the PDF group increased from 2760±113 m/s at term to 2877±90 m/s and 3032±60 m/s at three and six months corrected age, respectively (P<0.001). Likewise, bone SOS of the TF group increased from 2695±116 m/s at term to 2846±72 and 2978±83 m/s at three and six months, respectively (P<0.001). No statistically significant difference was found between the groups in terms of growth and bone SOS measurements. The levels of both bone turnover markers decreased significantly during the study period (P<0.001 for both groups).
Conclusion: Feeding with PDF after term had no short-term beneficial effect on bone strength and bone turn-over of VLBW infants.
©2007 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?
- Clinical-radiological features of fractures in premature infants – a review
- Scientific and religious controversies about the beginning of human life: the relevance of the ethical concept of the fetus as a patient
- The status of the embryo in Buddhism: opinions on scientific and religious controversies about the beginning of human life
- The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes
- Validity of amniotic fluid index in preterm rupture of membranes
- Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations
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- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to cardiotocography to predict fetal acidosis in labor / A multi-center, case controlled study
- Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses
- MRI and multiplanar 3D ultrasound compared in the prenatal assessment of enlarged posterior fossa
- Monochorionic twins in which at least one fetus has a congenital heart disease with or without twin-twin transfusion syndrome
- Enriched post-discharge formula versus term formula for bone strength in very low birth weight infants: a longitudinal pilot study
- Which information will be given to parents of preterm infants – a comparison of estimates and local data
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Impact of being small-for-gestational age on survival and long-term outcome of extremely premature infants born at 23–27 weeks' gestation
- Gastroschisis: brief early history
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