Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial
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Roni Levy
Abstract
Aim: To evaluate the efficacy and safety of oral misoprostol for labor induction in women with term premature rupture of membranes (PROM) and an unfavorable cervix.
Methods: We randomized 130 women with PROM of ≤4 h to either oral misoprostol, 50 μg, or a placebo given every 4 h for up to three doses. Intravenous oxytocin was initiated if active labor did not begin within 12 h.
Results: Sixty-four women received oral misoprostol and 66 received placebo. The PROM-to-delivery interval was shorter with misoprostol than with placebo (13.7±5.8 vs. 20.3±6.8 h, respectively, P<0.05). Misoprostol significantly reduced the need for oxytocin (28.1 vs. 72.7%, P<0.001) and antibiotics (25 vs. 69.7%, P<0.001). No significant differences in cesarean section or hyperstimulation rate were noted.
Conclusion: Oral misoprostol given to women with unfavorable cervix soon after term PROM significantly reduces the induction-to-delivery time and the need for oxytocin and antibiotics.
References
1 ACOG Committee Opinion: Number 283, May 2003: New US Food and Drug Administration Labeling on Cytotec (Misoprostol) Use and Pregnancy. Obstet Gynecol 101 (2003) 1049Suche in Google Scholar
2 Alfirevic Z: Oral misoprostol for induction of labor (Cochrane Review). In: Cochrane library, Issue 3. John Wiley and Sons Ltd., Chichester, UK 2004Suche in Google Scholar
3 Al-Hussaini TK, SA Abder Aal, MA Youssef: Oral misoprostol vs. intravenous oxytocin for labor induction in women with prelabor rupture of membranes at term. Int J Gynaecol Obstet82 (2003) 73Suche in Google Scholar
4 Chua S: Premature rupture of membranes in nuliparas at term with unfavorable cervices: A double-blind randomized trial of prostaglandin and placebo. Obstet Gynecol86(1996) 55010.1016/0029-7844(95)00214-CSuche in Google Scholar
5 Crane JM, T Delaney, D Hutchens: Oral misoprostol for premature rupture of membranes at term. Am J Obstet Gynecol189 (2003) 720Suche in Google Scholar
6 Duff P, RW Huff, RS Gibbs: Management of premature rupture of membranes and unfavourable cervix at term pregnancy. Obstet Gynecol63 (1984) 697Suche in Google Scholar
7 Garris RE, CF Kirkwood: Misoprostol: a prostaglandin E1 analogue. Clin Pharmacol8 (1989) 627Suche in Google Scholar
8 Goldenberg AB, MB Greenberg, PD Darney: Misoprostol and pregnancy. N Engl J Med344 (2001) 38Suche in Google Scholar
9 Gunn GC, DR Mishell Jr, DG Morton: Premature rupture of fetal membranes: a review. Am J Obstet Gynecol106(1970) 46910.1016/0002-9378(70)90378-9Suche in Google Scholar
10 Hannah ME, A Ohlsson, D Farine, SA Hewson, ED Hodnett, TL Myhr, et al.: Induction of labor compared with expectant management for prelabor rupture of the membranes at term. N Engl J Med334 (1996) 1005Suche in Google Scholar
11 Hoffman RA, J Anthony, JA Fawcus: Oral misoprostol vs. placebo in the management of prelabor rupture of membranes at term. Int J Obstet Gynecol72 (2001) 215Suche in Google Scholar
12 Hofmeyer GJ, AM Gulmezoglu: Vaginal misoprostol for cervical ripening and induction of labor (Cochrane Review). In: Cochrane library, Issue 3. John Wiley and Sons Ltd., Chichester, UK 2004Suche in Google Scholar
13 Kappy KA, CL Cettrulo, RA Knuppel, CJ Ingardia, AJ Sbarra, JC Scerbo: Premature rupture of membranes at term: a comparision of induced and spontaneous labors. J Reprod Med27 (1982) 29Suche in Google Scholar
14 Lin MG, FS Nuthalapaty, AR Carver, AS Case, PS Ramsey: Misoprostol for labor induction in women with term premature rupture of membranes. A meta-analysis. Obstet Gynecol106 (2005) 593Suche in Google Scholar
15 Lo JY, JM Alexander, DD McIntire, KJ Leveno: Ruptured membranes at term: randomized, double-blind trial of oral misoprostol for labor induction. Obstet Gynecol101 (2003) 685Suche in Google Scholar
16 Natale R, K Milne, K Campbell, PGG Potts, K Webster, E Halinda: Management of premature rupture of membranes at term: Randomized trial. Am J Obstet Gynecol171(1994) 93610.1016/S0002-9378(94)70062-1Suche in Google Scholar
17 Ngai SW, WK To, T Lao, PC Ho: Cervical priming with oral misoprostol in pre-labor rupture of membranes at term. Obstet Gynecol87 (1996) 923Suche in Google Scholar
18 Ramsey PS, KD Ramin, SM Ramin: Labor induction. Curr Opin Obstet Gynecol12 (2000) 463Suche in Google Scholar
19 Sanchez-Ramos L, AH Chen, AM Kaunitz, FL Gaudier, I Delke: Labor induction with intravaginal misoprostol in term premature rupture of membranes: A randomized study. Obstet Gynecol89 (1997) 909Suche in Google Scholar
20 Shetty A, K Stewart, G Stewart, P Rice, P Danielian, A Templeton: Active management of term prelabour rupture of membranes with oral misoprostol. Br J Obstet Gynaecol109 (2002) 1354Suche in Google Scholar
21 Wing DA: Labor induction with misoprostol. Am J Obstet Gynecol181 (1999) 33910.1016/S0002-9378(99)70558-2Suche in Google Scholar
©2007 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- To all readers, authors and subscribers
- The relationship between periodontal disease, bacterial vaginosis, and preterm birth
- Does raising the glucose challenge test threshold impact birthweight in Asian gravidas?
- Puerperal complications following elective cesarean sections for twin pregnancies
- Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women
- Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex
- Uteroplacental circulation, preeclampsia, and maternal abdominal aortic stiffness in normal and compromised pregnancies
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial
- Reference intervals for the cross sectional area of the umbilical cord during gestation
- The combined effect of betamethasone and ritodrine on the middle cerebral artery in low risk third trimester pregnancies
- Association between peak serum bilirubin and severity of respiratory distress syndrome in infants of less than 30 weeks' gestation
- Ranitidine and late-onset sepsis in the neonatal intensive care unit
- Outcome of infants born at 21–28 weeks' gestation in an inner-city hospital over an eight-year period
- Detection rate of Helicobacter pylori stool antigen in newborn infants and small children
- The potential role of high or low birthweight as risk factor for adult schizophrenia
- Multiple vascular accidents: Pentalogy of Cantrell in one twin with left sided colonic atresia in the second twin
- Solitary hepatic lymphangioma in an infant
- Spontaneous twin pregnancy in a 56-year-old primipara
- Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions
- Congress Calendar
