Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial
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Roni Levy
Abstract
Aim: To evaluate the efficacy and safety of oral misoprostol for labor induction in women with term premature rupture of membranes (PROM) and an unfavorable cervix.
Methods: We randomized 130 women with PROM of ≤4 h to either oral misoprostol, 50 μg, or a placebo given every 4 h for up to three doses. Intravenous oxytocin was initiated if active labor did not begin within 12 h.
Results: Sixty-four women received oral misoprostol and 66 received placebo. The PROM-to-delivery interval was shorter with misoprostol than with placebo (13.7±5.8 vs. 20.3±6.8 h, respectively, P<0.05). Misoprostol significantly reduced the need for oxytocin (28.1 vs. 72.7%, P<0.001) and antibiotics (25 vs. 69.7%, P<0.001). No significant differences in cesarean section or hyperstimulation rate were noted.
Conclusion: Oral misoprostol given to women with unfavorable cervix soon after term PROM significantly reduces the induction-to-delivery time and the need for oxytocin and antibiotics.
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©2007 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- To all readers, authors and subscribers
- The relationship between periodontal disease, bacterial vaginosis, and preterm birth
- Does raising the glucose challenge test threshold impact birthweight in Asian gravidas?
- Puerperal complications following elective cesarean sections for twin pregnancies
- Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women
- Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex
- Uteroplacental circulation, preeclampsia, and maternal abdominal aortic stiffness in normal and compromised pregnancies
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial
- Reference intervals for the cross sectional area of the umbilical cord during gestation
- The combined effect of betamethasone and ritodrine on the middle cerebral artery in low risk third trimester pregnancies
- Association between peak serum bilirubin and severity of respiratory distress syndrome in infants of less than 30 weeks' gestation
- Ranitidine and late-onset sepsis in the neonatal intensive care unit
- Outcome of infants born at 21–28 weeks' gestation in an inner-city hospital over an eight-year period
- Detection rate of Helicobacter pylori stool antigen in newborn infants and small children
- The potential role of high or low birthweight as risk factor for adult schizophrenia
- Multiple vascular accidents: Pentalogy of Cantrell in one twin with left sided colonic atresia in the second twin
- Solitary hepatic lymphangioma in an infant
- Spontaneous twin pregnancy in a 56-year-old primipara
- Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions
- Congress Calendar
