Role of surfactant inhibitors in amniotic fluid in respiratory distress syndrome
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I. Štucin Gantar
Abstract
Aim. In vitro studies and animal experiments have provided evidence that albumin, bilirubin, meconium and inflammatory mediators act as surfactant inhibitors. The aim of this research was to establish whether their elevated concentrations in gastric aspirates, as representative samples of amniotic fluid, could contribute to the development of respiratory distress syndrome (RDS) in preterm infants.
Methods. Infants born before the 35th week of gestation between 1 March 1996 and 1 April 1997 were included. They were divided into two groups: the RDS and non RDS group. Gastric aspirates, taken immediately after birth, were used for biochemical measurements of albumin, bilirubin, meconium and E-α1-PI concentrations.
Results. Sixty-one preterm infants were enrolled: 23 in the RDS group. The concentrations of albumin, bilirubin and meconium in gastric aspirates were higher in the RDS group (p < 0.01, p = 0.01 and p = 0.02, respectively). The E-α1-PI concentration showed no significant difference between the two groups. Logistic regression analysis showed that a markedly increased risk of RDS was only represented by albumin concentrations of over 1.6 mmol/l and gestational age of under 31 weeks.
Conclusion. Our observations indicate that increased levels of albumin in the gastric aspirate, taken immediately after birth, may contribute to the development of RDS in preterm infants. Despite the established inhibitory effects of bilirubin, meconium and inflammatory mediators in vitro, we could not confirm their influence on the development of RDS.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Editorial
- The odds of delivering one, two or three extremely low birth weight (<1000 g) triplet infants: a study of 3288 sets
- Evaluation of a device for objective determination of cervical consistency: A pilot study of devices validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease
- Clinical risk factors for deep venous thrombosis in pregnancy and the puerperium
- Waterbirth: water temperature and bathing time mother knows best!
- Anal sphincter injury during vaginal delivery – an argument for cesarean section on request?
- Doppler sonography of uterine arteries at 20–23 weeks: risk assessment of adverse pregnancy outcome by quantification of impedance and notch
- Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women
- The effects of oral carbohydrate administration on fetal acid base balance
- Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium
- Catch-up growth in fetal malnourished term infants
- Role of surfactant inhibitors in amniotic fluid in respiratory distress syndrome
- Congenital tuberculosis proven by percutaneous liver biopsy: report of a case
- A case of peripartum cardiomyopathy with a transient increase of plasma interleukin-6 concentration occurred following mirror syndrome
- Bilateral cystic adenomatoid lung malformation type III – a rare differential diagnosis of pulmonary hypertension in neonates
- An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone
- Urethral catheterization in neonates – how far is too far?
- Congress Calendar
