The effect of chlorophorin and its derivative on melanin biosynthesis
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Enos Tangke Arung
Abstract
By means of bioassay-guided fractionation using mushroom tyrosinase, a geranylated stilbene, chlorophorin, was characterized as the principal tyrosinase inhibitor in the heartwood of Chlorophora excelsa (Moraceae). It inhibited the oxidation of L-tyrosine and DL-3,4-dihydroxyphenylalanine (DL-DOPA) due to mushroom tyrosinase and melanin biosynthesis on B16 melanoma cells. Chlorophorin, which is a slight yellowish compound, has previously been reported as an unstable compound in light. On the basis of this finding, a chlorophorin derivative [4-(3″,7″-dimethyloctyl)-2′,3,4′,5-tetrahydroxydihydrostilbene; hexahydrochlorophorin] which is colorless, obtained by the hydrogenation of chlorophorin with Pd/C, was also tested to develop a superior material for practical use. Hexahydrochlorophorin showed more potent inhibitory activity on tyrosinase and melanin biosynthesis, and lower cytotoxicity towards B16 melanoma cells than chlorophorin.
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©2005 by Walter de Gruyter Berlin New York
Articles in the same Issue
- The prediction of pulp yield using selected fiber properties
- Surface lignin and extractives on hardwood RDH kraft pulp chemically characterized by ToF-SIMS
- NMR studies on Fraser fir Abies fraseri (Pursh) Poir. lignins
- Acid hydrolysis kinetics and identification of erythro and threo α-ethyl ether derivatives of non-phenolic arylglycerol-β-syringyl ether lignin model compounds
- Stabilization of cellulose solutions in N-methylmorpholine-N-oxide (Lyocell dopes) by addition of an N-oxide as sacrificial substrate
- Mechanism of decomposition of peracetic acid by manganese ions and diethylenetriaminepentaacetic acid (DTPA)
- The effect of chlorophorin and its derivative on melanin biosynthesis
- Long-term development of VOC emissions from OSB after hot-pressing
- Assessment of continuous distribution of wood properties from a low number of samples: Application to the variability of modulus of elasticity between trees and within a tree
- Earlywood and latewood elastic properties in loblolly pine
- Combined shear and compression analysis using a modified Iosipescu shear test device. Experimental studies on dry wood
- An approach to viscoelastic behaviour analysis of wood-based panels by an inverse method of characterisation
- The mechanosorptive effect in Pinus radiata D. Don.
- Advances in understanding bioactivity of chitosan and chitosan oligomers against selected wood-inhabiting fungi
- Comparison of quantitative real-time PCR, chitin and ergosterol assays for monitoring colonization of Trametes versicolor in birch wood
- Rate and extent of adsorption of ACQ preservative components in wood
- Prediction of long-term leaching potential of preservative-treated wood by diffusion modeling
Articles in the same Issue
- The prediction of pulp yield using selected fiber properties
- Surface lignin and extractives on hardwood RDH kraft pulp chemically characterized by ToF-SIMS
- NMR studies on Fraser fir Abies fraseri (Pursh) Poir. lignins
- Acid hydrolysis kinetics and identification of erythro and threo α-ethyl ether derivatives of non-phenolic arylglycerol-β-syringyl ether lignin model compounds
- Stabilization of cellulose solutions in N-methylmorpholine-N-oxide (Lyocell dopes) by addition of an N-oxide as sacrificial substrate
- Mechanism of decomposition of peracetic acid by manganese ions and diethylenetriaminepentaacetic acid (DTPA)
- The effect of chlorophorin and its derivative on melanin biosynthesis
- Long-term development of VOC emissions from OSB after hot-pressing
- Assessment of continuous distribution of wood properties from a low number of samples: Application to the variability of modulus of elasticity between trees and within a tree
- Earlywood and latewood elastic properties in loblolly pine
- Combined shear and compression analysis using a modified Iosipescu shear test device. Experimental studies on dry wood
- An approach to viscoelastic behaviour analysis of wood-based panels by an inverse method of characterisation
- The mechanosorptive effect in Pinus radiata D. Don.
- Advances in understanding bioactivity of chitosan and chitosan oligomers against selected wood-inhabiting fungi
- Comparison of quantitative real-time PCR, chitin and ergosterol assays for monitoring colonization of Trametes versicolor in birch wood
- Rate and extent of adsorption of ACQ preservative components in wood
- Prediction of long-term leaching potential of preservative-treated wood by diffusion modeling
