Article
Licensed
Unlicensed
Requires Authentication
Definition of reference ranges for the platelet distribution width (PDW): a local need
-
Published/Copyright:
December 4, 2009
Abstract
Background: Automated hematological analyzers have contributed to more precise and faster results. They also make it possible to measure several blood cell parameters automatically. Among the parameters provided, platelet indices are probably the most ignored by clinical laboratories due to the difficulty of standardization, as well as being affected by a range of methodological problems. It has been suggested that each laboratory determines its own reference intervals with the equipment used.
Methods: Our goal was to determine the reference range of platelet distribution width (PDW) in venous blood samples from 231 patients using the Pentra 120 ABX hematology analyzer.
Results: The PDW median was 13.3%, with a reference range of 10.0%–17.9% for the 5th–95th percentiles, with a confidence interval of 95%.
Conclusions: Among all indices, the PDW has been receiving attention due to its usefulness for distinguishing between reactive thrombocytosis and thrombocytosis associated with myeloproliferative disorder. Determination of the PDW reference range is fundamental, and the association of this parameter with the platelet number and mean platelet volume may be used for the diagnosis and differentiation of several pathologies.
Clin Chem Lab Med 2010;48:255–7.
Received: 2009-7-18
Accepted: 2009-9-23
Published Online: 2009-12-04
Published in Print: 2010-02-01
©2010 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Review
- Elevated serum γ-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer – a narrative review
- Minireview
- Artificial intelligence for diagnostic purposes: principles, procedures and limitations
- General Clinical Chemistry and Laboratory Medicine
- Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006
- Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults
- Plasma osteopontin concentrations in preeclampsia – is there an association with endothelial injury?
- Determination of globotriaosylceramide in plasma and urine by mass spectrometry
- Effect of inflammation induced by prolonged exercise on circulating erythroid progenitors and markers of erythropoiesis
- The Beckman DxI 800 prolactin assay demonstrates superior specificity for monomeric prolactin
- Stability of cerebrospinal fluid/serum glucose ratio and cerebrospinal fluid lactate concentrations over 24 h: analysis of repeated measurements
- O-β-N-acetyl-D-glucosaminidase in erythrocytes of Italian air force acrobatic pilots
- Validation and Outcome Studies
- Experimental validation of specificity of the squamous cell carcinoma antigen-immunoglobulin M (SCCA-IgM) assay in patients with cirrhosis
- Performance analysis of the ARCHITECT anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis
- Reference Values and Biological Variations
- Applicability of common reference intervals for serum creatinine concentrations to the Croatian population
- Laboratory reference intervals during pregnancy, delivery and the early postpartum period
- Determination of serum holotranscobalamin concentrations with the AxSYM active B12 assay: cut-off point evaluation in the clinical laboratory
- Definition of reference ranges for the platelet distribution width (PDW): a local need
- Cancer Diagnostics
- Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
- Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma
- Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels
- A novel sensitive immunoassay by nucleic acid barcode dot and its application in the detection of prostate-specific antigen
- Prostate cancer screening: clinical impact of WHO calibration of Beckman Coulter Access® prostate-specific antigen assays
- Infectious Diseases
- Use of flow cytometry (Sysmex® UF-100) to screen for positive urine cultures: in search for the ideal cut-off
- Letters to the Editor
- Improving laboratory efficiencies through significant time reduction in the preanalytical phase
- Comparison of the Vitek 2 system with the CLSI broth microdilution, disk diffusion, and sterol quantitation methods for determining fluconazole susceptibility against Candida spp.
Articles in the same Issue
- Review
- Elevated serum γ-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer – a narrative review
- Minireview
- Artificial intelligence for diagnostic purposes: principles, procedures and limitations
- General Clinical Chemistry and Laboratory Medicine
- Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006
- Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults
- Plasma osteopontin concentrations in preeclampsia – is there an association with endothelial injury?
- Determination of globotriaosylceramide in plasma and urine by mass spectrometry
- Effect of inflammation induced by prolonged exercise on circulating erythroid progenitors and markers of erythropoiesis
- The Beckman DxI 800 prolactin assay demonstrates superior specificity for monomeric prolactin
- Stability of cerebrospinal fluid/serum glucose ratio and cerebrospinal fluid lactate concentrations over 24 h: analysis of repeated measurements
- O-β-N-acetyl-D-glucosaminidase in erythrocytes of Italian air force acrobatic pilots
- Validation and Outcome Studies
- Experimental validation of specificity of the squamous cell carcinoma antigen-immunoglobulin M (SCCA-IgM) assay in patients with cirrhosis
- Performance analysis of the ARCHITECT anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis
- Reference Values and Biological Variations
- Applicability of common reference intervals for serum creatinine concentrations to the Croatian population
- Laboratory reference intervals during pregnancy, delivery and the early postpartum period
- Determination of serum holotranscobalamin concentrations with the AxSYM active B12 assay: cut-off point evaluation in the clinical laboratory
- Definition of reference ranges for the platelet distribution width (PDW): a local need
- Cancer Diagnostics
- Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
- Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma
- Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels
- A novel sensitive immunoassay by nucleic acid barcode dot and its application in the detection of prostate-specific antigen
- Prostate cancer screening: clinical impact of WHO calibration of Beckman Coulter Access® prostate-specific antigen assays
- Infectious Diseases
- Use of flow cytometry (Sysmex® UF-100) to screen for positive urine cultures: in search for the ideal cut-off
- Letters to the Editor
- Improving laboratory efficiencies through significant time reduction in the preanalytical phase
- Comparison of the Vitek 2 system with the CLSI broth microdilution, disk diffusion, and sterol quantitation methods for determining fluconazole susceptibility against Candida spp.
