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Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction
-
Xiang Xie
Veröffentlicht/Copyright:
1. März 2009
Abstract
Background: Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS) are enzymes involved in prostaglandin and prostacyclin synthesis, which have been linked to cardiovascular disease risk. We hypothesized that genetic variations altering the function of these enzymes would modify the risk of myocardial infarction (MI).
Methods: In a Chinese case control study of MI patients (n=356) and healthy controls (n=350), we investigated the roles of polymorphisms in the PGIS gene (CYP8A1) and the COX-2 gene (PTGS2) using polymerase chain reaction-restriction fragment length polymorphism analysis.
Results: The CC genotype of CYP8A1 and the –765CC genotype of PTGS2 were more common in the MI patients than in the control subjects (p=0.041, p=0.012, respectively). The odds ratio (OR) estimated by the combined analysis for the CYP8A1 CC and PTGS2 –765CC genotypes [OR=5.44; 95% confidence interval (CI): 3.12–7.23] was markedly higher than that estimated separately for the CYP8A1 CC genotype (OR=1.37; 95% CI: 0.95–2.85) or the PTGS2 –765CC genotype (OR=2.92; 95% CI: 1.78–5.76) alone.
Conclusions: The CC genotype of CYP8A1 or the –765CC genotype of PTGS2 is associated with MI, respectively. Furthermore, the significantly combined effects of these two gene variants in the arachidonic acid metabolic pathway indicate that combining the effects of a modest number of genes, whose products are known to act in a pathophysiological manner, could be a useful method to explore the association of genetic polymorphisms and polygenic inheritance disease.
Clin Chem Lab Med 2009;47:347–52.
Received: 2008-10-1
Accepted: 2008-12-29
Published Online: 2009-03-01
Published in Print: 2009-03-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
cyclooxygenase-2;
gene polymorphism;
myocardial infarction;
prostacyclin synthase
Artikel in diesem Heft
- Dipeptidyl peptidases and related proteins: Editorial
- Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets
- Dipeptidyl peptidases and related proteins: Reviews
- Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
- Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
- Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease
- Dipeptidyl peptidases and related proteins: Original Papers
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- Original Papers
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- Genetics and Molecular Diagnostics
- A selected pre-amplification strategy for genetic analysis using limited DNA targets
- Automated cell disruption is a reliable and effective method of isolating RNA from fresh snap-frozen normal and malignant oral mucosa samples
- General Clinical Chemistry and Laboratory Medicine
- Serum free light chain immunoassay as an adjunct to serum protein electrophoresis and immunofixation electrophoresis in the detection of multiple myeloma and other B-cell malignancies
- Gas chromatography/mass spectrometry screening of serum metabolomic biomarkers in hepatitis B virus infected cirrhosis patients
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- Letters to the Editor
- A preliminary evaluation of the AQT90 FLEX TnI immunoassay
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- The degree of knowledge shown by physicians in relation to the variability of laboratory test results
