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Plasma osteoprotegerin is an independent risk factor for mortality and an early biomarker of coronary vascular calcification in chronic kidney disease

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Published/Copyright: February 10, 2009
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 47 Issue 3

Abstract

Background: Cardiovascular disease is the major cause of morbidity and mortality in chronic kidney disease (CKD) and early biomarkers are required which can predict disease and death in such patients. The aim of our study was to investigate if osteoprotegerin (OPG) could be a predictor of coronary artery calcification (CAC) and mortality in CKD.

Methods: A total of 77 outpatients (32 with pre-dialysis CKD and 45 undergoing hemodialysis) were followed-up during 2 years. Measurements of CAC were performed using Siemens Multidetector CT software and calcium scores were measured according to the Agatston method.

Results: OPG was an independent predictor of the Agatston score for CAC and correlated with the degree of CAC in pre-dialysis patients. A two-sample t-test characterized survivors as having a better glomerular filtration rate, lower Agatston scores, and lower serum levels of OPG. Kaplan-Meier survival curves separated survivors from non-survivors at plasma OPG cut-off levels of <3.1 ng/mL. A multivariable logistic regression analysis showed that OPG was an independent predictor of mortality from all causes in CKD patients.

Conclusions: OPG predicted mortality in CKD patients and could be a valuable biomarker in early detection of CAC in these patients.

Clin Chem Lab Med 2009;47:339–46.

Keywords: arteriosclerosis; cardiovascular disease; chronic kidney disease; hemodialysis; osteoprotegerin (OPG); vascular calcification
Corresponding author: Maria Mesquita, Department of Nephrology and Dialysis, CHU Brugmann, Place A Van Gehuchten 4, 1020 Bruxelles, Belgium
Received: 2008-9-18
Accepted: 2008-12-18
Published Online: 2009-02-10
Published in Print: 2009-03-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2009.075
Keywords for this article
arteriosclerosis; cardiovascular disease; chronic kidney disease; hemodialysis; osteoprotegerin (OPG); vascular calcification

Articles in the same Issue

  1. Dipeptidyl peptidases and related proteins: Editorial
  2. Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets
  3. Dipeptidyl peptidases and related proteins: Reviews
  4. Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
  5. Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
  6. Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease
  7. Dipeptidyl peptidases and related proteins: Original Papers
  8. Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
  9. Original Papers
  10. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions
  11. Genetics and Molecular Diagnostics
  12. A selected pre-amplification strategy for genetic analysis using limited DNA targets
  13. Automated cell disruption is a reliable and effective method of isolating RNA from fresh snap-frozen normal and malignant oral mucosa samples
  14. General Clinical Chemistry and Laboratory Medicine
  15. Serum free light chain immunoassay as an adjunct to serum protein electrophoresis and immunofixation electrophoresis in the detection of multiple myeloma and other B-cell malignancies
  16. Gas chromatography/mass spectrometry screening of serum metabolomic biomarkers in hepatitis B virus infected cirrhosis patients
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  19. Cardiovascular Diseases
  20. Expression of heme oxygenase-1, hypoxia inducible factor-1α, and ubiquitin in peripheral inflammatory cells from patients with coronary heart disease
  21. Vitamin B12 deficiency is associated with coronary artery disease in an Indian population
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  23. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction
  24. Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes
  25. Validation and Outcome Studies
  26. Evaluation of the BD Vacutainer® PST™ II Blood Collection Tube for special chemistry analytes
  27. Higher parathyroid hormone (PTH) concentrations with the Architect PTH assay than with the Elecsys assay in hemodialysis patients, and a simple way to standardize these two methods
  28. Precision performance at low levels and 99th percentile concentration of the Access® AccuTnI® assay on two different platforms
  29. Guidelines and Recommendations
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