Startseite Vitamin B12 deficiency is associated with coronary artery disease in an Indian population
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Vitamin B12 deficiency is associated with coronary artery disease in an Indian population

  • Jitender Kumar , Gaurav Garg , Elayanambi Sundaramoorthy , P. Veerendra Prasad , Ganesan Karthikeyan , Lakshmy Ramakrishnan , Saurabh Ghosh und Shantanu Sengupta
Veröffentlicht/Copyright: 4. Februar 2009
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Clinical Chemistry and Laboratory Medicine
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine Band 47 Heft 3

Abstract

Background: The incidence of coronary artery disease (CAD) is increasing at an alarming rate, especially in developing countries, such as India. It is often advocated that a vegetarian lifestyle could reduce the burden of CAD. However, in spite of a majority of Indians being vegetarians, the incidence of CAD is highest in this population. This may be due to deficiency of vitamin B12, a micronutrient, sourced only from animal products.

Methods: Herein, we assessed the effect of vitamin B12 with respect to CAD in 816 individuals (368 CAD patients and 448 controls) recruited from a tertiary care center in New Delhi, India.

Results: We found that vitamin B12 levels were significantly lower in CAD patients than in controls (p<0.0001). Also, vegetarians were found to have significantly lower vitamin B12 concentrations (p=0.0001) and higher incidence of CAD (p=0.01). Interestingly, elevated homocysteine levels, a hallmark of vitamin B12 deficiency, was not associated with CAD. In contrast, cysteine levels were significantly higher in CAD patients than in controls (p=0.004).

Conclusions: We believe that, when vitamin B12 is deficient, homocysteine is rapidly metabolized via the transsulfuration pathway leading to increased cysteine levels.

Clin Chem Lab Med 2009;47:334–8.

Keywords: coronary artery disease; cysteine; homocysteine; vegetarian diet; vitamin B12
Corresponding author: Shantanu Sengupta, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007 Phone: +91-11-27666156, Fax: +91-11-27667471,
Received: 2008-10-30
Accepted: 2008-12-18
Published Online: 2009-02-4
Published in Print: 2009-03-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2009.074
Schlagwörter für diesen Artikel
coronary artery disease; cysteine; homocysteine; vegetarian diet; vitamin B12

Artikel in diesem Heft

  1. Dipeptidyl peptidases and related proteins: Editorial
  2. Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets
  3. Dipeptidyl peptidases and related proteins: Reviews
  4. Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
  5. Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions
  6. Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease
  7. Dipeptidyl peptidases and related proteins: Original Papers
  8. Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
  9. Original Papers
  10. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions
  11. Genetics and Molecular Diagnostics
  12. A selected pre-amplification strategy for genetic analysis using limited DNA targets
  13. Automated cell disruption is a reliable and effective method of isolating RNA from fresh snap-frozen normal and malignant oral mucosa samples
  14. General Clinical Chemistry and Laboratory Medicine
  15. Serum free light chain immunoassay as an adjunct to serum protein electrophoresis and immunofixation electrophoresis in the detection of multiple myeloma and other B-cell malignancies
  16. Gas chromatography/mass spectrometry screening of serum metabolomic biomarkers in hepatitis B virus infected cirrhosis patients
  17. Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers
  18. Sensitive and specific ELISA coated by TpN15-TpN17-TpN47 fusion protein for detection of antibodies to Treponema pallidum
  19. Cardiovascular Diseases
  20. Expression of heme oxygenase-1, hypoxia inducible factor-1α, and ubiquitin in peripheral inflammatory cells from patients with coronary heart disease
  21. Vitamin B12 deficiency is associated with coronary artery disease in an Indian population
  22. Plasma osteoprotegerin is an independent risk factor for mortality and an early biomarker of coronary vascular calcification in chronic kidney disease
  23. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction
  24. Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes
  25. Validation and Outcome Studies
  26. Evaluation of the BD Vacutainer® PST™ II Blood Collection Tube for special chemistry analytes
  27. Higher parathyroid hormone (PTH) concentrations with the Architect PTH assay than with the Elecsys assay in hemodialysis patients, and a simple way to standardize these two methods
  28. Precision performance at low levels and 99th percentile concentration of the Access® AccuTnI® assay on two different platforms
  29. Guidelines and Recommendations
  30. The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: Code of Conduct, Version 2 – 2008
  31. Letters to the Editor
  32. A preliminary evaluation of the AQT90 FLEX TnI immunoassay
  33. Automated validation of clinical laboratory test results: do we get what we expect?
  34. The degree of knowledge shown by physicians in relation to the variability of laboratory test results
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