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Can E-cadherin and CD34 be used as indicators of prognosis for hepatocellular carcinoma patients?
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Li-Qun Wu
Published/Copyright:
August 1, 2008
Abstract
Backgroud: The high postoperative recurrence of hepatocellular carcinoma (HCC) is a problem that would benefit from the identification of indicators of recurrence and prognosis. In the past few years, research has shown that E-cadherin and CD34 can be used as indicators of the invasion of malignant tumors. In the present study, we investigated the expression of E-cadherin and CD34 in HCC patients.
Methods: Expression levels of E-cadherin and CD34 in 41 HCC samples were detected using two-step immunohistochemical methods and compared with clinical pathological parameters and survival rate.
Results: The positive rates of E-cadherin and CD34 expression in 41 HCC cases were 48.78% and 100%, respectively. Expression of E-cadherin was significantly lower in patients with larger tumors, a high risk invasion and Edmondson classification III or IV (p<0.05). There was a significant relationship between CD34 expression and age and tumor invasiveness (p<0.05). There was no significant relationship between expression of CD34 and E-cadherin by Spearman statistical analysis (p>0.05). The survival rate in patients with negative expression of E-cadherin was significantly lower.
Conclusions: The expression of CD34 cannot be used singly as a prognostic indicator for HCC patients. The co-expression of E-cadherin and CD34 cannot be used as a prognostic indicator for HCC patients.
Clin Chem Lab Med 2008;46:1122–6.
Received: 2008-2-5
Accepted: 2008-3-31
Published Online: 2008-08-01
Published in Print: 2008-08-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
E-cadherin;
CD34;
co-expression;
hepatocellular carcinoma;
prognostic indicator
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- Minireview
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