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Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behçet's disease patients
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Nadia Koubaa
Veröffentlicht/Copyright:
13. Dezember 2007
Abstract
Background: Behçet's disease (BD) is a multisystemic immuno-inflammatory disorder. Inflammatory processes may cause lipid peroxidation, alteration of lipid profile and increase the risk of atherosclerosis. The aim of this study was to evaluate the association between thiolactonase (HTLase) activity and plasma homocysteine levels (tHcy) in a BD population and to investigate their association with methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype.
Method: A total of 35 BD patients were compared to 39 healthy volunteers.
Results: Significantly higher tHcy levels associated with lower HTLase activities were found in BD patients as compared to healthy controls (p<0.001). These patients also exhibited lower values of triglycerides and high-density lipoprotein cholesterol (HDL-C). Homozygosity for the T allele of the MTHFR gene was more frequent in BD patients (14.3% vs. 7.7%). It was associated with significantly higher tHcy levels (16.9 μmol/L for n=17 vs. 13.1 μmol/L for n=18; p<0.05) and markedly lower HTLase activity (362.6±156.7 U/L vs. 414.2±180.2 U/L) for the (TT+CT) and CC genotypes, respectively. Moreover, HDL-C levels were inversely correlated with tHcy (r=–0.5; p=0.004) but positively associated with HTLase activity (r=0.374; p=0.038). These correlations were also present in several clinical manifestations, such as ocular, neurological involvement or thrombosis.
Conclusions: Homozygosity of the T allele of the MTHFR gene is prevalent in BD patients. High levels of tHcy associated with low HTLase activities may be one of the causes leading to thrombosis in BD patients.
Clin Chem Lab Med 2008;46:187–92.
Keywords: Behçet's disease; homocysteine; lipids; methylenetetrahydrofolate reductase polymorphism; thiolactonase
Received: 2007-8-2
Accepted: 2007-10-16
Published Online: 2007-12-13
Published in Print: 2008-02-01
©2008 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Behçet's disease;
homocysteine;
lipids;
methylenetetrahydrofolate reductase polymorphism;
thiolactonase
Artikel in diesem Heft
- Opinion Papers
- The double whammy of endogenous insulin antibodies in non-diabetic subjects
- ‘Likelihood-ratio’ and ‘odds’ applied to monitoring of patients as a supplement to ‘reference change value’ (RCV)
- Genetics and Molecular Diagnostics
- A family with multiple mutations and sequence variations in the α- and β-globin gene clusters
- CTLA-4 polymorphism 49A–G is associated with placental abruption and preeclampsia in Finnish women
- Rare TA repeats in promoter TATA box of the UDP glucuronosyltranferase (UGT1A1) gene in Croatian subjects
- Association of high sensitive C-reactive protein with apolipoprotein E polymorphism in children and young adults: The Cardiovascular Risk in Young Finns Study
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- A rapid and sensitive method to detect specific human lymphocyte antigen (HLA) class II alleles associated with celiac disease
- General Clinical Chemistry and Laboratory Medicine
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- N-Terminal proB-type natriuretic peptide (NT-proBNP) concentrations in elite rugby players at rest and after active and passive recovery following strenuous training sessions
- Strenuous exercise activates growth factors and chemokines over-expression in human serum of top-level triathlon athletes during a competitive season
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