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Changes in serum fetuin-A and inflammatory markers levels in end-stage renal disease (ESRD): effect of a single session haemodialysis
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Marcello Ciaccio
Published/Copyright:
December 13, 2007
Abstract
Background: The aim of the present study was to evaluate the effect of a single haemodialysis (HD) session on serum fetuin-A levels, considered a negative acute phase response marker; moreover, we evaluated the behaviour of fibrinogen and high sensitivity C-reactive protein (hsCRP) as acute phase response and chronic/subclinical inflammation markers, respectively, after a single HD session.
Methods: Serum fetuin-A, albumin, hsCRP and fibrinogen were measured in 72 patients before and after a single HD session.
Results: After a single HD session, we observed a significant increase in fibrinogen levels, while fetuin-A levels decreased (p<0.05). Also, hsCRP levels were significantly increased.
Conclusions: The significant decrease of fetuin-A levels after a single HD session is consistent with the hypothesis of HD-induced inflammation; activated acute phase response and fetuin-A deficiency might account for increased cardiovascular risk and accelerated atherogenesis in dialysis patients.
Clin Chem Lab Med 2008;46:212–4.
Received: 2007-8-22
Accepted: 2007-10-5
Published Online: 2007-12-13
Published in Print: 2008-02-01
©2008 by Walter de Gruyter Berlin New York
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Articles in the same Issue
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- ‘Likelihood-ratio’ and ‘odds’ applied to monitoring of patients as a supplement to ‘reference change value’ (RCV)
- Genetics and Molecular Diagnostics
- A family with multiple mutations and sequence variations in the α- and β-globin gene clusters
- CTLA-4 polymorphism 49A–G is associated with placental abruption and preeclampsia in Finnish women
- Rare TA repeats in promoter TATA box of the UDP glucuronosyltranferase (UGT1A1) gene in Croatian subjects
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