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The −374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients
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Geraldo Picheth
Published/Copyright:
October 10, 2007
Abstract
Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been associated with diabetes, coronary artery disease (CAD) and inflammatory processes. The –374T>A RAGE gene promoter polymorphism was shown to affect gene transcription. The aim of this study was to evaluate the association of the –374T>A polymorphism with the severity of CAD in patients with or without type 2 diabetes mellitus.
Methods: We studied 246 Euro-Brazilians with angiographically defined CAD (stenosis >50%), comprising type 2 diabetic (n=98) and non-diabetic subjects (n=148). Genotyping was performed by PCR-restriction fragment length polymorphism using Tsp509I restriction enzyme.
Results: The AA genotype was associated with a significant decrease in CAD severity estimated by the number of diseased vessels (1.43±0.5 vs. 2.49±1.1; p=0.002) and the Duke score (27.3±10.8 vs. 49.3±20.1; p=0.001) only in the group of CAD subjects with type 2 diabetes mellitus. The protective effect of the AA genotype against severity of CAD was not observed in the non-diabetic group.
Conclusion: This result confirms that the –374AA genotype of the RAGE gene promoter is a protective factor against the severity of CAD lesions in type 2 diabetic patients.
Clin Chem Lab Med 2007;45:1268–72.
Keywords: advanced glycation end products; coronary artery disease; disease severity; Euro-Brazilians; risk factor; single nucleotide polymorphism; type 2 diabetes
Received: 2007-1-12
Accepted: 2007-6-1
Published Online: 2007-10-10
Published in Print: 2007-10-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
advanced glycation end products;
coronary artery disease;
disease severity;
Euro-Brazilians;
risk factor;
single nucleotide polymorphism;
type 2 diabetes
Articles in the same Issue
- Atrial natriuretic peptide and related peptides
- The −374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients
- Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes
- CD36 polymorphism and its relationship with body mass index and coronary artery disease in a Korean population
- Preservation of RNA for functional analysis of separated alleles in yeast: comparison of snap-frozen and RNALater® solid tissue storage methods
- Mother-child double incompatibility at vWA and D5S818 loci in paternity testing
- Matrix metalloprotease-2 and -9 concentration and activity in serum and culture medium samples: a methodological reappraisal
- Are changes in blood-ethanol concentration during storage analytically significant? Importance of method imprecision
- Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry
- The soluble transferrin receptor reflects tumor load in chronic lymphocytic leukemia
- Calculated low-density lipoprotein cholesterol remains a viable and important test for screening and targeting therapy
- Angiotensin-converting enzyme (ACE) I/D corrected serum ACE activity and severity assessment of community-acquired pneumonia
- Differentiating transudative from exudative pleural effusion: should we measure effusion cholesterol dehydrogenase?
- Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort
- Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology
- Use of a solid-phase extraction with radioimmunoassay to identify the proportional bias of clinical B-type natriuretic peptide immunoassay: the impact of plasma matrix and antibody multispecificity
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