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Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”

  • Masao Kanauchi , Kimiko Kanauchi , Tomoko Inoue , Kuniko Kimura and Yoshihiko Saito
Published/Copyright: January 1, 2007
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 45 Issue 1

Abstract

Background: There are few data on the impact of insulin resistance on the recently defined categories of prehypertension (PHT) and prediabetes (PDM). The aim of this study was to examine associations of surrogate markers of insulin resistance with PHT/PDM.

Methods: Subjects included 554 individuals who underwent a 75-g oral glucose tolerance test (OGTT). They were classified into four groups using a severity score for high blood pressure and glucose tolerance. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-R) and three surrogate markers obtained from 75-g OGTT values (ISI-composite, Stumvoll index, and OGIS index).

Results: HOMA-R increased significantly, but the other three surrogate indices decreased with increasing severity score. Of these markers, the OGIS index was mostly associated with prevalent PHT/PDM and the odds ratio for insulin resistance was 3.61 (95% CI 1.68–7.76, p=0.001) for subjects with either PHT or PDM and 29.98 (12.81–70.18, p<0.001) for subjects with both PHT and PDM.

Conclusions: PHT and PDM frequently coexist in relatively lean Japanese subjects. Decreased insulin sensitivity may contribute to the underlying status of PHT/PDM. Among the surrogate markers of insulin resistance, the OGIS index is the most sensitive for assessment of PHT/PDM status.

Clin Chem Lab Med 2007;45:35–9.

Keywords: insulin resistance; metabolic syndrome; prediabetes; prehypertension; 75-g oral glucose tolerance test
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Corresponding author: Dr. Masao Kanauchi, First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-0813, Japan Phone: +81-744-223051, Fax: +81-744-281880,

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Published Online: 2007-01-01
Published in Print: 2007-01-01

©2007 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2007.015
Keywords for this article
insulin resistance; metabolic syndrome; prediabetes; prehypertension; 75-g oral glucose tolerance test

Articles in the same Issue

  1. CCLM: Bringing advances in laboratory medicine to the “New World”
  2. Diagnostic approach to inherited bleeding disorders
  3. Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
  4. Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area
  5. Anti-thyroid-stimulating hormone receptor antibodies determined by second-generation assay
  6. Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients
  7. Surrogate markers of insulin resistance in assessing individuals with new categories “prehypertension” and “prediabetes”
  8. Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability
  9. Hyperhomocysteinaemia and immune activation in patients with cancer
  10. The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
  11. Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
  12. Pregnancy-associated plasma protein A in dialysis patients
  13. L-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities
  14. Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease
  15. Increased adenosine deaminase in hydatidiform mole
  16. Classification tree analysis for the discrimination of pleural exudates and transudates
  17. External quality assessment of hemoglobin A2 measurement: data from an Italian pilot study with fresh whole blood samples and commercial HPLC systems
  18. Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine
  19. Interchangeability of measurements of CA 19-9 in serum with four frequently used assays: an update
  20. Analytical validation of the new version of the Liaison N-Tact PTH assay
  21. Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
  22. Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method
  23. Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
  24. Acquiring a measurement system within the framework of standard ISO 15189
  25. Six Sigma and laboratory consultation
  26. ESR or LSRB, that is the question!
  27. Reply to the Letter written by Hardeman
  28. Natriuretic peptides. The hormones of the heart
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