Home Medicine N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias
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N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias

  • Martina Brueckmann , Thomas Bertsch , Ursula Hoffmann , Siegfried Lang , Jens J. Kaden , Christian Wolpert , Guenter Huhle , Martin Borggrefe and Karl K. Haase
Published/Copyright: June 1, 2005

Abstract

Radiofrequency (RF) catheter ablation has been shown to be highly effective in the treatment of supraventricular tachycardias. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (B-type natriuretic peptide; BNP) are secreted by the heart mainly in response to myocardial stretch induced by volume load. The aim of the present study was to determine the time course of the N-terminal prohormone forms of ANP (NT-proANP) and BNP (NT-proBNP) in patients undergoing radiofrequency (RF) catheter ablation for paroxysmal supraventricular tachycardias.

Serial blood samples were taken from 13 patients with symptomatic paroxysmal supraventricular tachycardias undergoing RF ablation and from 13 age- and gender-matched healthy controls. Blood was taken before ablation (day 0, baseline), and at day one and day 120 after ablation. Levels of NT-proANP were significantly higher before RF ablation (4862 ± 726 pmol/l) as compared to day one (2021 ± 220 pmol/l) and day 120 after RF ablation (2470 ± 349 pmol/l) (with p < 0.01 on day one and p < 0.05 on day 120; n = 13). The size of the left atrium decreased from 41.0 ± 5.5 mm before ablation to 34.9 ± 5.9 mm (n = 13; p < 0.05) on day 120 as measured by M-mode echocardiography. Levels of NT-proBNP showed comparable values before and on day one and day 120 after ablation and were not significantly elevated as compared to healthy controls.

NT-proANP levels are increased in patients presenting with paroxysmal supraventricular tachycardias and decrease one day after radiofrequency catheter ablation, possibly reflecting a transient reduction of ANP secretion from injured myocardial cells. Lower NT-proANP levels in the long-term time course may result from reduction of atrial volume load and reconstitution of atrial architecture after successful treatment of supraventricular tachycardias. NT-proANP may serve as a useful laboratory marker to describe the long-term interventional success after RF ablation.


Corresponding author: Martina Brueckmann, MD, First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Phone and Fax: 0049-621-383-2875, E-mail:

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Received: 2004-1-22
Accepted: 2004-6-15
Published Online: 2005-6-1
Published in Print: 2004-8-1

© Walter de Gruyter

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