The Application of Clinical Proteomics to Cancer and other Diseases
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William Clarke
Abstract
The term “clinical proteomics” refers to the application of available proteomics technologies to current areas of clinical investigation. The ability to simultaneously and comprehensively examine changes in large numbers of proteins in the context of disease or other changes in physiological conditions holds great promise as a tool to unlock the solutions to difficult clinical research questions. Proteomics is a rapidly growing field that combines high throughput analytical methodologies such as two-dimensional gel electrophoresis and SELDI mass spectrometry methods with complex bioinformatics to study systems biology–the system of interest is defined by the investigator. Even with all its potential, however, studies must be carefully designed in order to differentiate true clinical differences in protein expression from differences originating from variation in sample collection, variation in experimental condition, and normal biological variability. Proteomic analyses are already widely in use for clinical studies ranging from cancer to other diseases such as cardiovascular disease, organ transplant, and pharmacodynamic studies.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Mass Spectrometry in Laboratory Medicine
- Mass Spectrometry-Based Proteomics: Current Status and Potential Use in Clinical Chemistry
- Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease
- The Application of Clinical Proteomics to Cancer and other Diseases
- Therapeutic Drug Monitoring of 13 Antidepressant and Five Neuroleptic Drugs in Serum with Liquid Chromatography-Electrospray Ionization Mass Spectrometry
- Mass Spectrometric Analysis of Human Transferrin in Different Body Fluids
- Profiling and in vivo Quantification of Proteins by High Resolution Mass Spectrometry: The Example of Goserelin, an Analogue of Luteinizing Hormone-Releasing Hormone
- Determination of Nicotine and Its Major Metabolite Cotinine in Plasma or Serum by Gas Chromatography-Mass Spectrometry Using Ion-Trap Detection
- Analysis of Nitrofuran Metabolites in Food by High-Performance Liquid Chromatography with Tandem Mass Spectrometry Detection
- Automated LC-MS Method for the Fast Stereoselective Determination of Methadone in Plasma
- Proteome Analysis of Diseased Joints from Mice Suffering from Collagen-Induced Arthritis
- Quantitative Analysis of Bile Acids in Human Plasma by Liquid Chromatography-Electrospray Tandem Mass Spectrometry: A Simple and Rapid One-Step Method
- Organic Acids in the Second Morning Urine in a Healthy Swiss Paediatric Population
- Acknowledgement
- Meetings and Awards
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Mass Spectrometry in Laboratory Medicine
- Mass Spectrometry-Based Proteomics: Current Status and Potential Use in Clinical Chemistry
- Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease
- The Application of Clinical Proteomics to Cancer and other Diseases
- Therapeutic Drug Monitoring of 13 Antidepressant and Five Neuroleptic Drugs in Serum with Liquid Chromatography-Electrospray Ionization Mass Spectrometry
- Mass Spectrometric Analysis of Human Transferrin in Different Body Fluids
- Profiling and in vivo Quantification of Proteins by High Resolution Mass Spectrometry: The Example of Goserelin, an Analogue of Luteinizing Hormone-Releasing Hormone
- Determination of Nicotine and Its Major Metabolite Cotinine in Plasma or Serum by Gas Chromatography-Mass Spectrometry Using Ion-Trap Detection
- Analysis of Nitrofuran Metabolites in Food by High-Performance Liquid Chromatography with Tandem Mass Spectrometry Detection
- Automated LC-MS Method for the Fast Stereoselective Determination of Methadone in Plasma
- Proteome Analysis of Diseased Joints from Mice Suffering from Collagen-Induced Arthritis
- Quantitative Analysis of Bile Acids in Human Plasma by Liquid Chromatography-Electrospray Tandem Mass Spectrometry: A Simple and Rapid One-Step Method
- Organic Acids in the Second Morning Urine in a Healthy Swiss Paediatric Population
- Acknowledgement
- Meetings and Awards
