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Mass Spectrometry-Based Proteomics: Current Status and Potential Use in Clinical Chemistry
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Pierre-Alain Binz
Published/Copyright:
June 1, 2005
Abstract
For some years now, scientists have been spending a lot of effort in developing methods to analyse and compare complex protein samples. One of the goals of such global analyses of what is known as proteomes is to discover specific protein markers–or fingerprints of protein markers−from various types of affected biological samples. Considering the battery of technologies currently available, mass spectrometry (MS) constitutes an essential tool in proteomics. We describe here the type of MS instrumentation that is currently dedicated to proteomics research. We also describe the major experimental workflows that are typically used in proteomics today, with a focus on those incorporating MS as a major analysis tool.
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Published Online: 2005-06-01
Published in Print: 2003-12-04
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Mass Spectrometry in Laboratory Medicine
- Mass Spectrometry-Based Proteomics: Current Status and Potential Use in Clinical Chemistry
- Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease
- The Application of Clinical Proteomics to Cancer and other Diseases
- Therapeutic Drug Monitoring of 13 Antidepressant and Five Neuroleptic Drugs in Serum with Liquid Chromatography-Electrospray Ionization Mass Spectrometry
- Mass Spectrometric Analysis of Human Transferrin in Different Body Fluids
- Profiling and in vivo Quantification of Proteins by High Resolution Mass Spectrometry: The Example of Goserelin, an Analogue of Luteinizing Hormone-Releasing Hormone
- Determination of Nicotine and Its Major Metabolite Cotinine in Plasma or Serum by Gas Chromatography-Mass Spectrometry Using Ion-Trap Detection
- Analysis of Nitrofuran Metabolites in Food by High-Performance Liquid Chromatography with Tandem Mass Spectrometry Detection
- Automated LC-MS Method for the Fast Stereoselective Determination of Methadone in Plasma
- Proteome Analysis of Diseased Joints from Mice Suffering from Collagen-Induced Arthritis
- Quantitative Analysis of Bile Acids in Human Plasma by Liquid Chromatography-Electrospray Tandem Mass Spectrometry: A Simple and Rapid One-Step Method
- Organic Acids in the Second Morning Urine in a Healthy Swiss Paediatric Population
- Acknowledgement
- Meetings and Awards
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Mass Spectrometry in Laboratory Medicine
- Mass Spectrometry-Based Proteomics: Current Status and Potential Use in Clinical Chemistry
- Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease
- The Application of Clinical Proteomics to Cancer and other Diseases
- Therapeutic Drug Monitoring of 13 Antidepressant and Five Neuroleptic Drugs in Serum with Liquid Chromatography-Electrospray Ionization Mass Spectrometry
- Mass Spectrometric Analysis of Human Transferrin in Different Body Fluids
- Profiling and in vivo Quantification of Proteins by High Resolution Mass Spectrometry: The Example of Goserelin, an Analogue of Luteinizing Hormone-Releasing Hormone
- Determination of Nicotine and Its Major Metabolite Cotinine in Plasma or Serum by Gas Chromatography-Mass Spectrometry Using Ion-Trap Detection
- Analysis of Nitrofuran Metabolites in Food by High-Performance Liquid Chromatography with Tandem Mass Spectrometry Detection
- Automated LC-MS Method for the Fast Stereoselective Determination of Methadone in Plasma
- Proteome Analysis of Diseased Joints from Mice Suffering from Collagen-Induced Arthritis
- Quantitative Analysis of Bile Acids in Human Plasma by Liquid Chromatography-Electrospray Tandem Mass Spectrometry: A Simple and Rapid One-Step Method
- Organic Acids in the Second Morning Urine in a Healthy Swiss Paediatric Population
- Acknowledgement
- Meetings and Awards
