Article
Licensed
Unlicensed
Requires Authentication
Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss
-
Mirande Candito
Published/Copyright:
June 1, 2005
Abstract
Moderate hyperhomocysteinaemia (HHcy) and the homozygous mutation C677T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are associated with increased risk of recurrent pregnancy loss. This HHcy is currently reported as a consequence of folate rather than of vitamin B12-deficient status. We describe one case of recurrent early pregnancy loss with HHcy caused by B12 deficiency. A 38-year old woman had four episodes of early spontaneous pregnancy loss. Biological data: no haemostasis disorders, HHcy (25.9 μmol/l), normal folate (5 ng/ml), B12 deficiency (<150 pg/ml) and the MTHFR C677T homozygote genotype. A bone marrow biopsy gave evidence of moderate megaloblastosis. Parenteral B12 therapy led to normal homocysteine level within 2 months and to a successful pregnancy. In conclusion, vitamin B12 deficiency is one of the causes of recurrent pregnancy loss associated with HHcy, and serum B12 should be measured systematically in this circumstance.
:
Published Online: 2005-06-01
Published in Print: 2003-08-07
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- SIBioC 2003 35th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Florence, Italy, 14–17 October 2003
- Vitamins and Trace Elements: The Distances between Deficiency and Repletion and between Care and Prevention
- Factors Affecting Intestinal Absorption of Highly Lipophilic Food Microconstituents (Fat-Soluble Vitamins, Carotenoids and Phytosterols)
- Protective Effects of Antioxidant Micronutrients (Vitamin E, Zinc and Selenium) in Type 2 Diabetes Mellitus
- Biofactors in the Mediterranean Diet
- The Effect of Selenium on Immune Functions of J774.1 Cells
- Effects of Vitamin B12 and Folate Deficiencies on DNA Methylation and Carcinogenesis in Rat Liver
- Trace Elements, Innate Immune Response and Parasites
- Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss
- Low Frequency of Mutated Methylenetetrahydrofolate Reductase 677 C→T and 1298 A→C Genetics Single Nucleotide Polymorphisms (SNPs) in Sub-Saharan Populations
- A Two-Step Method for the Extraction of High-Quality RNA from Endoscopic Biopsies
- Assay for Cross-Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) Unlike CrossLaps Assay Reflects Increased Pathological Degradation of Type I Collagen in Rheumatoid Arthritis
- Stimulatory Effect of Homocysteine on Interleukin-8 Expression in Human Endothelial Cells
- Sensitive and Specific Photometric Determination of Mannitol in Human Serum
- Assessment of Hypolactasia and Site-Specific Intestinal Permeability by Differential Sugar Absorption of Raffinose, Lactose, Sucrose and Mannitol
- Human Plasminogen Is Highly Susceptible to Peroxynitrite Inactivation
- Analytical and Clinical Evaluation of a New Urinary Tumor Marker: Bladder Tumor Fibronectin in Diagnosis and Follow-up of Bladder Cancer
- Biological Variation of Lipoprotein(a) in a Diabetic Population. Analysis of the Causes and Clinical Implications
- Relationship of Dehydroepiandrosterone and Its 7-Hydroxylated Metabolites to Thyroid Parameters and Sex Hormone-Binding Globulin (SHBG) in Healthy Subjects
- Comparability of Eight Immunoassay Procedures for the Determination of CA 15-3 and Related Markers
- Reference Values of Serum Total Sialic Acid for Healthy Adult Subjects and Comparison of Two Different Calibrators for Quantitation of Total Sialic Acid in High Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection
- A Simple Method for the Classification of Proteinuria
- Meetings and Awards
Articles in the same Issue
- SIBioC 2003 35th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Florence, Italy, 14–17 October 2003
- Vitamins and Trace Elements: The Distances between Deficiency and Repletion and between Care and Prevention
- Factors Affecting Intestinal Absorption of Highly Lipophilic Food Microconstituents (Fat-Soluble Vitamins, Carotenoids and Phytosterols)
- Protective Effects of Antioxidant Micronutrients (Vitamin E, Zinc and Selenium) in Type 2 Diabetes Mellitus
- Biofactors in the Mediterranean Diet
- The Effect of Selenium on Immune Functions of J774.1 Cells
- Effects of Vitamin B12 and Folate Deficiencies on DNA Methylation and Carcinogenesis in Rat Liver
- Trace Elements, Innate Immune Response and Parasites
- Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss
- Low Frequency of Mutated Methylenetetrahydrofolate Reductase 677 C→T and 1298 A→C Genetics Single Nucleotide Polymorphisms (SNPs) in Sub-Saharan Populations
- A Two-Step Method for the Extraction of High-Quality RNA from Endoscopic Biopsies
- Assay for Cross-Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) Unlike CrossLaps Assay Reflects Increased Pathological Degradation of Type I Collagen in Rheumatoid Arthritis
- Stimulatory Effect of Homocysteine on Interleukin-8 Expression in Human Endothelial Cells
- Sensitive and Specific Photometric Determination of Mannitol in Human Serum
- Assessment of Hypolactasia and Site-Specific Intestinal Permeability by Differential Sugar Absorption of Raffinose, Lactose, Sucrose and Mannitol
- Human Plasminogen Is Highly Susceptible to Peroxynitrite Inactivation
- Analytical and Clinical Evaluation of a New Urinary Tumor Marker: Bladder Tumor Fibronectin in Diagnosis and Follow-up of Bladder Cancer
- Biological Variation of Lipoprotein(a) in a Diabetic Population. Analysis of the Causes and Clinical Implications
- Relationship of Dehydroepiandrosterone and Its 7-Hydroxylated Metabolites to Thyroid Parameters and Sex Hormone-Binding Globulin (SHBG) in Healthy Subjects
- Comparability of Eight Immunoassay Procedures for the Determination of CA 15-3 and Related Markers
- Reference Values of Serum Total Sialic Acid for Healthy Adult Subjects and Comparison of Two Different Calibrators for Quantitation of Total Sialic Acid in High Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection
- A Simple Method for the Classification of Proteinuria
- Meetings and Awards
