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Are Results of Fibrinogen Measurements Transferable?
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Anders Kallner
Published/Copyright:
June 1, 2005
Abstract
Fibrinogen concentration is routinely measured by several methods and the results may influence diagnostic and treatment strategies. It is therefore necessary that results are compatible and transferable between laboratories. In the present study, it is shown that commonly used immuno-nephelometric methods, a commercial variant of the Clauss clotting rate method, and the classical syneresis method, do not differ significantly using patient material, in the interval 2–12 g/l. A research ELISA method that measures intact fibrinogen is not linearly correlated to the syneresis method. The commutability of available calibrators and reference materials (including the WHO 2nd IS) was only 50–80% except for one of the calibrators for which the virtual concentration coincided with that obtained by the
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Published Online: 2005-06-01
Published in Print: 2003-06-17
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Editorial
- Biomedical Applications of Capillary Electrophoresis
- Capillary Electrophoresis – A High Performance Analytical Separation Technique
- The Analysis of Carbohydrate-Deficient Transferrin, Marker of Chronic Alcoholism, Using Capillary Electrophoresis
- Capillary Electrophoresis of Hemoglobin
- Capillary Electrophoresis for the Determination of Organic Acidurias in Body Fluids: A Review
- Separation of Serum Proteins by Automated Capillary Zone Electrophoresis
- Is Capillary Electrophoresis a Method of Choice for Systematic Toxicological Analysis?
- Capillary Zone Electrophoresis of Serum Proteins: Effects of Changed Analytical Conditions
- Type-Specific Detection of Human Papillomaviruses in a Routine Laboratory Setting – Improved Sensitivity and Specificity of PCR and Sequence Analysis Compared to Direct Hybridisation
- Identification of Lipoproteins of Intestinal Origin in Human Atherosclerotic Plaque
- Molecular Cloning, Sequencing and Functional Expression of Porcine Thyrotropin (TSH) Receptor cDNA
- Are Results of Fibrinogen Measurements Transferable?
- Comparison of Several Point-of-Care Testing (POCT) Glucometers with an Established Laboratory Procedure for the Diagnosis of Type 2 Diabetes Using the Discordance Rate. A New Statistical Approach
- Association between Increased Serum Cholesterol and Signs of Depressive Mood
- Report from the Second European Symposium on Clinical Laboratory and in vitro Diagnostic Industry. Physiological Reference Values: A Shared Business? Barcelona, 67 February 2003
- Meetings and Awards
