Gender Differences in C-Reactive Protein Concentrations - Confirmation with Two Sensitive Methods
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Joseph P. McConnell
Abstract
Two new automated, highly sensitive methods for the measurement of C-reactive protein (CRP) were compared using blood samples from active and retired health care workers (116 males, 114 females). The regression equation was y=1.115x−0.0267 for the Kamiya K assay immunoturbidimetric method (x) vs. the Behring BNII nephelometric method (y) with medians (IQR) of 0.156 (0.081 to 0.276) and 0.150 (0.060 to 0.240) mg/dl, respectively. Significant differences in hsCRP values between males and females were observed (p=0.013 and p=0.0018 for Behring and Kamiya methods, respectively). This gender difference in CRP levels was confirmed by analysis of serum samples from 1114 individuals (639 males and 475 females) obtained through Mayo Medical Laboratories reference services, which represents participants from across the United States. The gender difference, which was confirmed (p<0.0001), was independent of age differences as assessed by multiple regression analysis. The observed gender differences have important implications for the establishment of cut-off points for cardiovascular risk stratification.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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- Editorial
- Growing Significance of Myeloperoxidase in Non-infectious Diseases
- Serum Paraoxonase Activity and the Extent of Lipid Peroxidation Are not Affected by Increased Levels of Human Apolipoprotein A-I: Studies in Transgenic Mice
- Relationship between the Sialic Acid Content of Low-Density Lipoprotein (LDL) and Autoantibodies to Oxidized LDL in the Plasma of Healthy Subjects and Patients with Atherosclerosis
- The Presence of Heparin-Platelet Factor 4 Antibodies as a Marker of Hypercoagulability during Hemodialysis
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- Serum Cholinesterase Activity in Patients with Burns
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- Reference Intervals for a Complete Blood Count Determined on different Automated Haematology Analysers: Abx Pentra 120 Retic, Coulter Gen-S, Sysmex SE 9500, Abbott Cell Dyn 4000 and Bayer Advia 120
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