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Clinical Evaluation of Changes in the Morphology of Eosinophils
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Claudia J. Pronk-Admiraal
Published/Copyright:
June 1, 2005
Abstract
In order to diagnose and monitor patients with allergic diseases, we studied parameters which reflect not only the amount of eosinophils but also their state of activation. Morphologic features reveal additional information on the activity state of eosinophils.
The number of nuclear lobes, cell size, amount of vacuoles and density of specific granules are considered characteristic features of eosinophils.
We conclude that the size of eosinophils is a useful parameter to distinguish patients with and without eosinophilia.
The treatment with corticosteroids did not affect morphological characteristics such as the number of vacuoles, granulation density, cell diameter and the nucleus/cell surface ratio, but the number of lobes per nucleus, a marker of eosinophil maturation, decreased significantly.
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Published Online: 2005-06-01
Published in Print: 2002-01-29
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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- The n-3 and n-6 Polyunsaturated Fatty Acid Composition of Plasma Phospholipids in Pregnant Women and Their Infants. Relationship with Maternal Linoleic Acid Intake
- Quantification of Sirolimus by Liquid Chromatography-Tandem Mass Spectrometry Using On-Line Solid-Phase Extraction
- The Effects of Affinity-Purified Anti-DNA Antibodies Derived from Patients with Systemic Lupus Erythematosus on the Fluorescent Antinuclear Antibody Assay Using HEp-2 Cells
- Relationships between Serum Markers of Monocyte/Macrophage Activation in Type 1 Gaucher's Disease
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