Prognostic Significance of the Presence of Erythroblasts in Blood after Cardiothoracic Surgery
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Axel Stachon
Abstract
In patients suffering from a variety of severe diseases the detection of erythroblasts in peripheral blood is associated with poor prognosis. However, as yet the prognostic significance of erythroblasts in the blood of patients after cardiothoracic surgery has not been assessed. In a retrospective study we analyzed the database of 2074 patients, of whom 87 died in hospital during the postoperative period. All patients underwent cardiothoracic surgery using a heart-lung machine. Together with erythroblasts in blood, age, sex, body mass index, preoperative ejection fraction, smoking, diabetes mellitus, type of operation, emergency surgery, renal deficiency, pulmonary hypertension, and endocarditis were considered. The postoperative mortality of patients with erythroblasts in peripheral blood (n=57) was 45.6％ (n=26), being significantly higher (p﹤0.001) than the mortality of patients without erythroblasts (3.0％). None of six patients with more than 2000 erythroblasts x 106/l survived. The postoperative detection of erythroblasts is highly predictive of death, the odds ratio after adjustment for the other known prognostic factors being 7.2 (95％ confidence interval 3.4–15.1). Erythroblasts were detected for the first time on average 11 ±2 days (median: 7 days; n=57) after surgery and 8 ±2 days (median: 6 days; n=26) before death. The detection of erythroblasts in blood after cardiothoracic surgery has a high prognostic significance in terms of in-hospital mortality, helping physicians to identify patients at high risk of death. This finding has to be confirmed by a prospective study with the use of a more sensitive and reliable technology and prospectively defined time intervals for counting blood cells.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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- Prognostic Significance of the Presence of Erythroblasts in Blood after Cardiothoracic Surgery
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- Joshua Lederberg (Editor-in-Chief): Encyclopedia of Microbiology, 2nd Edition, Vol 1-4
Articles in the same Issue
- Autoantibodies Associated with Rheumatic Diseases
- Simultaneous Detection of Multiple Proteins with an Array-Based Enzyme-Linked Immunosorbent Assay (ELISA) and Enhanced Chemiluminescence (ECL)
- Hippuric Acid Test Using 13C-Labelling and NMR Spectroscopy
- Hippuric Acid as a Modifier of Calcium Oxalate Crystallisation
- Excretion of Sweat and Urine Pyridinoline Crosslinks in Healthy Controls and Subjects with Established Metabolic Bone Disease
- Hyperhomocysteinemia and Changed Plasma Thiol Redox Status in Chronic Obstructive Pulmonary Disease
- Biochemical Evaluation of Oxidative Stress during Exercise in Patients with Coronary Heart Disease
- Prognostic Significance of the Presence of Erythroblasts in Blood after Cardiothoracic Surgery
- Exploratory Biochemical Data Analysis: a Comparison of Two Sample Means and Diagnostic Displays
- Standardization of Laboratory Data and Establishment of Reference Intervals in the Fukuoka Prefecture: A Japanese Perspective
- Calibration, Specificity and Trueness of a Postheparin Plasma Lipoprotein Lipase Assay
- Analytical Performance of a Direct Assay for LDL-Cholesterol
- Genotyping Method for Point Mutation Detection in the Endothelial Nitric Oxide Synthase Exon 7 Using Fluorescent Probes. Clinical Validation in Systemic Sclerosis Patients
- IFCC Reference Measurement Procedure for Substance Concentration Determination of Total Carbon Dioxide in Blood, Plasma or Serum
- Joshua Lederberg (Editor-in-Chief): Encyclopedia of Microbiology, 2nd Edition, Vol 1-4
