Blood and Tissue Findings in the Diagnosis of Mesenteric Ischaemia: An Experimental study
-
Metin Aydın
Abstract
In this experimental study, after inducing mesenteric ischaemia in dogs, we investigated routine blood biochemistry, serum malondialdehyde (MDA) levels, histopathological changes and tissue MDA levels in the liver and intestines. The study group included 10 dogs. Six dogs which underwent sham operation served as controls. In the study group, the MDA level in liver tissue increased after superior mesenteric artery (SMA) ligation. Various degrees of necrosis were seen in the ileal biopsies 10 hours after the ligation. Hyperaemia and focal necrosis in the liver accompanied the intestinal necrosis if it was limited within the mucosa. However, massive or centrilobular necrosis was observed in the liver of those dogs which had intestinal necrosis that extended into muscular layers. MDA levels in intestinal tissue measured after SMA ligation were significantly higher than the preligation levels. On the other hand, the difference between serum and tissue MDA levels was not significant. The alterations in MDA were not significant in the sham group. Thus it is concluded that the serum MDA levels are valuable markers of diagnosis in intestinal ischaemia.
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Genetic Approach for Insulin-Independent Diabetes Mellitus in Clinical Practice
- An Enzymatic Method for the Determination of Free Fatty Acids in Serum/Plasma
- Specificity of Cardiac Troponins I and T in Renal Disease
- Blood and Tissue Findings in the Diagnosis of Mesenteric Ischaemia: An Experimental study
- Fucosylation and Galactosylation of IgG Heavy Chains Differ between Acute and Remission Phases of Juvenile Chronic Arthritis
- Analytical Evaluation of an Improved Procedure for Measuring Thyrotropin
- Erroneous Monocyte and Neutrophil Counts with the Sysmex NE-1500 in Patients Recovering from Bone Marrow Aplasia
- N-Benzoyl, L-Glutamic Acid as a Suitable Internal Standard for the Analysis of trans,trans-Muconic Acid in Human Urine by Liquid Chromatography
- Acute Exogenous Elevation of Plasma Free Fatty Acids Does Not Influence the Plasma Magnesium Concentration
- Characterisation and Evaluation of External Quality Assessment Scheme Serum
- Need for Correct Estimates of Biological Variation: The Example of C-Reactive Protein
Articles in the same Issue
- Genetic Approach for Insulin-Independent Diabetes Mellitus in Clinical Practice
- An Enzymatic Method for the Determination of Free Fatty Acids in Serum/Plasma
- Specificity of Cardiac Troponins I and T in Renal Disease
- Blood and Tissue Findings in the Diagnosis of Mesenteric Ischaemia: An Experimental study
- Fucosylation and Galactosylation of IgG Heavy Chains Differ between Acute and Remission Phases of Juvenile Chronic Arthritis
- Analytical Evaluation of an Improved Procedure for Measuring Thyrotropin
- Erroneous Monocyte and Neutrophil Counts with the Sysmex NE-1500 in Patients Recovering from Bone Marrow Aplasia
- N-Benzoyl, L-Glutamic Acid as a Suitable Internal Standard for the Analysis of trans,trans-Muconic Acid in Human Urine by Liquid Chromatography
- Acute Exogenous Elevation of Plasma Free Fatty Acids Does Not Influence the Plasma Magnesium Concentration
- Characterisation and Evaluation of External Quality Assessment Scheme Serum
- Need for Correct Estimates of Biological Variation: The Example of C-Reactive Protein
